THE EFFECT OF LOW MOLECULAR WEIGHT HEPARIN SODIUM IN THE TREATMENT OF ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE COMORBID WITH PULMONARY HEART DISEASE ON PROMOTING THE BALANCE OF BLOOD VESSELS.

Chronic obstructive pulmonary disease is a frequently occurring and common respiratory disease which has an incidence of 13.7% among people over 40 years in China, and now nearly 100 million people at home suffer from chronic obstructive pulmonary disease. To observe the effect of Low molecular weight heparin sodium in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) comorbid with pulmonary heart disease (PHD) on blood vessels.

Methods: A total of 92 patients with AECOPD accompanied by PHD in our Hospital from January 2019 to May 2021 were randomly divided into two groups. The control group was given basic treatment while the observation group was treated with basic treatment in combination with Low molecular weight heparin sodium. The changes of blood gas, hemorheology, cardiac function and serum factors were recorded to analyze their curative effect and safety.

Results: The total effective rate of the observation group was 95.65% (44 cases per 46 cases), which was significantly higher than that of the control group with 82.61% (38 cases per 46 cases), with statistical significance (P<0.05). The left ventricular ejection fraction (LVEF), 6-min walking distance (6MWD), arterial partial pressure of oxygen (PaO2), pH, nitric oxide (NO), and oxygen saturation (SaO2) in the two groups were higher than those before treatment while 4-hydroxymenealdehyde (4-HNE), endothelin-1 (ET-1), arterial partial pressure of carbon dioxide (PaCO2), brain natriuretic peptide (BNP), high-sensitivity-C-reactive protein (hs -CRP), tumor necrosis factor-α (TNF-α) and hemorheology indexes were decreased compared with those before treatment. After treatment, the improvement of the above indexes in the observation group was higher than those in the control group (P<0.05) with no significant difference in adverse reactions between them(P>0.05).

Conclusion: Low molecular weight heparin sodium can reduce inflammation and improve hemorheology by regulating the balance of blood vessels, thus improve the curative effect in the treatment of AECOPD accompanied by PHD.