鼻窦倒置乳头状瘤手术切除后复发的风险因素

IF 1 Q3 OTORHINOLARYNGOLOGY International Archives of Otorhinolaryngology Pub Date : 2024-05-25 eCollection Date: 2024-10-01 DOI:10.1055/s-0044-1785206
Eugénie Delaine, François Gorostidi, Pierre Guilcher, Karma Lambercy, Yann Litzistorf, Luc Bron, Antoine Reinhard
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摘要

简介:鼻窦倒置乳头状瘤(SNIP)是一种罕见的鼻腔和副鼻窦良性上皮肿瘤,分别占该解剖区域所有肿瘤的 0.4% 和 4.7%。目的 分析瑞士一家三级医疗中心鼻腔和副鼻窦良性上皮肿瘤手术切除后的疗效,并确定复发的风险因素。方法 我们对洛桑大学医院 2005 年至 2018 年间治疗的所有 SNIP 病例进行了回顾性研究。我们收集了患者和肿瘤的所有可用数据进行分析。我们研究了复发率,并寻找风险因素。结果 我们共收治了57名患者,平均年龄为55.5岁。原发病例 46 例(80.7%),复发病例 11 例(19.3%)。上颌窦是最常见的发病部位(33.3%)。根据克鲁斯(Krouse)分类法,约半数患者(52.6%)的肿瘤为T3。手术后的平均复发率为 17.5%,复发组患者(45.5%)的复发率高于原发病例(10.9%),达到统计学意义(比值比 [OR] = 6.8;95% 置信区间 [95%CI]:1.5-30.8;P<0.05):1.5-30.8; p = 0.0165).大多数患者接受了内窥镜治疗(94.7%)。额窦位置、较高的 Krouse 分期和联合方法似乎会增加复发风险,但无统计学意义。结论 手术入路困难(如肿瘤位于额窦)、疾病分期较高和曾接受过手术的病例切除不彻底和复发的风险较高。
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Risk Factors for Recurrence after Surgical Resection of Sinonasal Inverted Papilloma.

Introduction  Sinonasal inverted papilloma (SNIP) is a rare benign epithelial tumor of the nasal cavity and paranasal sinuses that accounts for 0.4% and 4.7% respectively, of all tumors of this anatomical region. Objective  To analyze the outcomes after surgical resection of SNIP and identify the risk factors for recurrence in a Swiss tertiary center. Methods  We conducted a retrospective review of all cases of SNIP treated at the Lausanne university hospital between 2005 and 2018. All data available on the patients and tumors were collected for analysis. We studied the recurrence rate and looked for risk factors. Results  We included 57 patients with a mean age of 55.5 years. There were 46 primary cases (80.7%) and 11 recurrences (19.3%). Maxillary sinus was the most frequent location (33.3%). Approximately half of the patients (52.6%) presented with a T3 tumor according to the Krouse classification. The mean recurrence rate after surgery was of 17.5% and it was more frequent among the patients in the recurrence group (45.5%) than among the primary cases (10.9%), reaching statistical significance (odds ratio [OR] = 6.8; 95% confidence interval [95%CI]: 1.5-30.8; p  = 0.0165). Most patients were treated endoscopically (94.7%). Frontal sinus location, higher Krouse stage, and combined approach seemed to increase the risk of recurrence, but without statistical significance. Conclusion  Difficult surgical access, as in the case of tumors located in the frontal sinus, higher stage of the disease, and previously operated cases carry the higher risk of incomplete resection and recurrence.

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CiteScore
2.80
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0.00%
发文量
84
审稿时长
12 weeks
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