谷胱甘肽作为皮肤美白剂和治疗黄褐斑:系统综述。

IF 3.5 4区 医学 Q1 DERMATOLOGY International Journal of Dermatology Pub Date : 2024-10-23 DOI:10.1111/ijd.17535
Rashmi Sarkar, Vidya Yadav, Twinkle Yadav, Janaani P, Irena Mandal
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引用次数: 0

摘要

包括黄褐斑在内的色素沉着病是一种难以治疗的疾病。谷胱甘肽具有抗黑色素生成和抗氧化特性,因此被用作皮肤美白剂。我们的目的是回顾已发表的有关谷胱甘肽作为皮肤美白剂和治疗黄褐斑的有效性和安全性的证据和文献。我们在 PubMed、Embase 和 Cochrane 图书馆数据库中使用 "谷胱甘肽作为皮肤美白剂 "和 "谷胱甘肽治疗黄褐斑 "这两个检索词对过去 10 年的文献进行了检索。对证据级别、推荐强度和偏倚风险进行了评估。在各种外用谷胱甘肽中,0.5%谷胱甘肽的效果明显优于0.1%谷胱甘肽和安慰剂。单用谷胱甘肽与谷胱甘肽加微针疗法相比,改善效果更明显。五项随机对照试验和一项开放式临床研究显示,与安慰剂相比,口服谷胱甘肽(250 毫克,一天一次;250 毫克,一天两次;500 毫克,一天一次)能显著降低黑色素指数。外用 2% 谷胱甘肽加口服谷胱甘肽的组合疗法优于单独的单一疗法。只有一项关于静脉注射谷胱甘肽的安慰剂对照研究[6/16 (37.5%) vs. 3 (18.7%),(p0.054)]。偏倚风险评估显示,几乎同等数量的研究存在低偏倚风险和高偏倚风险。外用谷胱甘肽和口服谷胱甘肽都能提供中度有效的美白皮肤效果,局部美白效果优于全身美白效果,不良反应轻微优于严重不良反应。由于缺乏疗效和副作用,静脉注射谷胱甘肽是禁忌的。谷胱甘肽作为一种抗氧化剂,可能对黄褐斑更有效。
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Glutathione as a skin-lightening agent and in melasma: a systematic review.

Hyperpigmentary disorders, including melasma, are challenging to treat. Glutathione has anti-melanogenic and antioxidant properties, which led to its use as a skin-lightening agent. Our objective was to review the published evidence and literature on the efficacy and safety of glutathione as a skin-lightening agent and in the treatment of melasma. A literature search was done in the PubMed, Embase, and Cochrane library databases using the search terms "glutathione as a skin-lightening agent" and "glutathione in melasma" for the past 10 years. The level of evidence, strength of recommendation, and risk of bias assessment were evaluated. Among various forms of topical glutathione, glutathione 0.5% was significantly more effective compared to glutathione 0.1% and placebo. For glutathione alone versus glutathione plus microneedling, more improvement was seen. Five randomized controlled trials and a single open-arm clinical study on oral glutathione at doses of 250 mg once a day, 250 mg twice a day, and 500 mg once a day showed a significant reduction in the melanin index compared to placebo. The combination of topical 2% glutathione plus oral glutathione was superior to monotherapy alone. There was only one placebo-controlled study on intravenous (IV) glutathione [6/16 (37.5%) vs. 3 (18.7%), (p0.054)]. The risk of bias assessment showed that almost an equal number of studies have low and high risk of bias. Topical versus oral glutathione both provide moderately efficacious skin-lightening outcomes that are localized versus generalized and have minimal versus substantial adverse effects, but they are unsustainable, with variable costs. IV glutathione is contraindicated due to lack of efficacy and side effects. It may work more as an antioxidant in melasma.

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来源期刊
CiteScore
4.70
自引率
2.80%
发文量
476
审稿时长
3 months
期刊介绍: Published monthly, the International Journal of Dermatology is specifically designed to provide dermatologists around the world with a regular, up-to-date source of information on all aspects of the diagnosis and management of skin diseases. Accepted articles regularly cover clinical trials; education; morphology; pharmacology and therapeutics; case reports, and reviews. Additional features include tropical medical reports, news, correspondence, proceedings and transactions, and education. The International Journal of Dermatology is guided by a distinguished, international editorial board and emphasizes a global approach to continuing medical education for physicians and other providers of health care with a specific interest in problems relating to the skin.
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