Briana M Nosal, Staci N Thornton, Alexey V Melnik, Ali Lotfi, Manije Darooghegi Mofrad, Alexander Aksenov, Elaine Choung-Hee Lee, Ock K Chun
{"title":"黑加仑花青素通过调节微生物衍生的短链羧酸和植物雌激素代谢物，减轻围绝经期和绝经后早期妇女因雌激素缺乏引起的骨质流失。","authors":"Briana M Nosal, Staci N Thornton, Alexey V Melnik, Ali Lotfi, Manije Darooghegi Mofrad, Alexander Aksenov, Elaine Choung-Hee Lee, Ock K Chun","doi":"10.3390/metabo14100541","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The present study aimed to assess the effects of blackcurrant (BC) anthocyanins on concentrations of microbial-derived short-chain carboxylic acids (SCCAs) and metabolites of phytoestrogens. We then examined their associations with six-month changes in whole-body bone mineral density (BMD) and biomarkers of bone metabolism.</p><p><strong>Methods: </strong>Fecal and blood samples from a pilot randomized controlled trial were collected and analyzed from 37 eligible peri- and early postmenopausal women aged 45-60 years who were randomized into one of three treatment groups consuming one placebo capsule (control), 392 mg BC (low BC) or 784 mg BC (high BC) daily for six months.</p><p><strong>Results: </strong>Significant differences were observed between groups at baseline in acetic, propionic, valeric, caproic and heptanoic acids (<i>p</i> < 0.05). Isobutyric acid significantly decreased from baseline (0 months) to six months in the control group (<i>p</i> < 0.05) and the high BC group had a significantly greater concentration than the control group at six months (<i>p</i> < 0.05). Butyric acid was significantly greater in the high BC group than low BC at six months (<i>p</i> < 0.05). Six-month changes in caproic and isobutyric acids showed weak correlations with changes in whole-body BMD (r = 0.3519, <i>p</i> < 0.05 and r = 0.3465, <i>p</i> < 0.05, respectively). Isovaleric and valeric acids displayed weak correlations with BALP (r = 0.3361, <i>p</i> < 0.05) and OPG (r = 0.3593, <i>p</i> < 0.05), respectively. Enterodiol was positively correlated with BALP (r = 0.6056, <i>p</i> < 0.01) while enterolactone was positively correlated with osteocalcin (r = 0.5902, <i>p</i> < 0.001) and negatively correlated with sclerostin (r = -0.3485, <i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>The results suggest that BC may be a potential dietary agent to reduce postmenopausal bone loss through modulating microbially-derived SCCAs and phytoestrogen metabolites.</p>","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"14 10","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11509583/pdf/","citationCount":"0","resultStr":"{\"title\":\"Blackcurrant Anthocyanins Attenuate Estrogen -Deficiency-Induced Bone Loss through Modulating Microbial-Derived Short-Chain Carboxylic Acids and Phytoestrogen Metabolites in Peri- and Early Postmenopausal Women.\",\"authors\":\"Briana M Nosal, Staci N Thornton, Alexey V Melnik, Ali Lotfi, Manije Darooghegi Mofrad, Alexander Aksenov, Elaine Choung-Hee Lee, Ock K Chun\",\"doi\":\"10.3390/metabo14100541\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>The present study aimed to assess the effects of blackcurrant (BC) anthocyanins on concentrations of microbial-derived short-chain carboxylic acids (SCCAs) and metabolites of phytoestrogens. We then examined their associations with six-month changes in whole-body bone mineral density (BMD) and biomarkers of bone metabolism.</p><p><strong>Methods: </strong>Fecal and blood samples from a pilot randomized controlled trial were collected and analyzed from 37 eligible peri- and early postmenopausal women aged 45-60 years who were randomized into one of three treatment groups consuming one placebo capsule (control), 392 mg BC (low BC) or 784 mg BC (high BC) daily for six months.</p><p><strong>Results: </strong>Significant differences were observed between groups at baseline in acetic, propionic, valeric, caproic and heptanoic acids (<i>p</i> < 0.05). Isobutyric acid significantly decreased from baseline (0 months) to six months in the control group (<i>p</i> < 0.05) and the high BC group had a significantly greater concentration than the control group at six months (<i>p</i> < 0.05). Butyric acid was significantly greater in the high BC group than low BC at six months (<i>p</i> < 0.05). Six-month changes in caproic and isobutyric acids showed weak correlations with changes in whole-body BMD (r = 0.3519, <i>p</i> < 0.05 and r = 0.3465, <i>p</i> < 0.05, respectively). Isovaleric and valeric acids displayed weak correlations with BALP (r = 0.3361, <i>p</i> < 0.05) and OPG (r = 0.3593, <i>p</i> < 0.05), respectively. Enterodiol was positively correlated with BALP (r = 0.6056, <i>p</i> < 0.01) while enterolactone was positively correlated with osteocalcin (r = 0.5902, <i>p</i> < 0.001) and negatively correlated with sclerostin (r = -0.3485, <i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>The results suggest that BC may be a potential dietary agent to reduce postmenopausal bone loss through modulating microbially-derived SCCAs and phytoestrogen metabolites.</p>\",\"PeriodicalId\":18496,\"journal\":{\"name\":\"Metabolites\",\"volume\":\"14 10\",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11509583/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Metabolites\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3390/metabo14100541\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Metabolites","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3390/metabo14100541","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Blackcurrant Anthocyanins Attenuate Estrogen -Deficiency-Induced Bone Loss through Modulating Microbial-Derived Short-Chain Carboxylic Acids and Phytoestrogen Metabolites in Peri- and Early Postmenopausal Women.
Objectives: The present study aimed to assess the effects of blackcurrant (BC) anthocyanins on concentrations of microbial-derived short-chain carboxylic acids (SCCAs) and metabolites of phytoestrogens. We then examined their associations with six-month changes in whole-body bone mineral density (BMD) and biomarkers of bone metabolism.
Methods: Fecal and blood samples from a pilot randomized controlled trial were collected and analyzed from 37 eligible peri- and early postmenopausal women aged 45-60 years who were randomized into one of three treatment groups consuming one placebo capsule (control), 392 mg BC (low BC) or 784 mg BC (high BC) daily for six months.
Results: Significant differences were observed between groups at baseline in acetic, propionic, valeric, caproic and heptanoic acids (p < 0.05). Isobutyric acid significantly decreased from baseline (0 months) to six months in the control group (p < 0.05) and the high BC group had a significantly greater concentration than the control group at six months (p < 0.05). Butyric acid was significantly greater in the high BC group than low BC at six months (p < 0.05). Six-month changes in caproic and isobutyric acids showed weak correlations with changes in whole-body BMD (r = 0.3519, p < 0.05 and r = 0.3465, p < 0.05, respectively). Isovaleric and valeric acids displayed weak correlations with BALP (r = 0.3361, p < 0.05) and OPG (r = 0.3593, p < 0.05), respectively. Enterodiol was positively correlated with BALP (r = 0.6056, p < 0.01) while enterolactone was positively correlated with osteocalcin (r = 0.5902, p < 0.001) and negatively correlated with sclerostin (r = -0.3485, p < 0.05).
Conclusions: The results suggest that BC may be a potential dietary agent to reduce postmenopausal bone loss through modulating microbially-derived SCCAs and phytoestrogen metabolites.
MetabolitesBiochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
5.70
自引率
7.30%
发文量
1070
审稿时长
17.17 days
期刊介绍：
Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.
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