缩小差距:纳米材料危害评估的创新性人体体外方法及其在安全和可持续设计、风险评估和生命周期评估中的作用。

IF 4.7 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES NanoImpact Pub Date : 2024-10-01 DOI:10.1016/j.impact.2024.100533
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引用次数: 0

摘要

纳米材料在工业和消费品中的应用呈指数级增长,这就要求在临床前分析中开发和使用预测性人体体外模型,以密切推断体内潜在的毒性效应。传统的纳米材料细胞毒性研究使用癌症细胞系,并在单层中进行二维培养,没有模拟适当的病理生理微环境,这可能会影响体外效应在体内水平的精确预测。近年来,人们利用细胞系、原代细胞或诱导多能干细胞(iPSCs),在单细胞到多细胞培养物中建立了复杂的体外模型(也属于新方法学,NAMs),并模拟体内条件重建成相关的生物维度。这些先进的体外模型保留了与生理相关的暴露情景,尤其适合纳米材料的口服、皮肤、呼吸和静脉注射,有可能提高体内可预测性并带来可靠的结果。在本视角中,我们讨论了使用先进的人体体外模型进行纳米材料危害评估的最新进展和突破。我们确定了将体外数据成功应用于纳米材料安全与可持续设计(SSbD)、风险评估(RA)和生命周期评估(LCA)的适用性要求和仍然存在的挑战。通过解决体外数据生成与体外数据在纳米材料安全评估中的实用性(SSbD 方法的先决条件)之间的差距,我们概述了未来发展的潜在关键领域。
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Bridging the gap: Innovative human-based in vitro approaches for nanomaterials hazard assessment and their role in safe and sustainable by design, risk assessment, and life cycle assessment
The application of nanomaterials in industry and consumer products is growing exponentially, which has pressed the development and use of predictive human in vitro models in pre-clinical analysis to closely extrapolate potential toxic effects in vivo. The conventional cytotoxicity investigation of nanomaterials using cell lines from cancer origin and culturing them two-dimensionally in a monolayer without mimicking the proper pathophysiological microenvironment may affect a precise prediction of in vitro effects at in vivo level. In recent years, complex in vitro models (also belonging to the new approach methodologies, NAMs) have been established in unicellular to multicellular cultures either by using cell lines, primary cells or induced pluripotent stem cells (iPSCs), and reconstituted into relevant biological dimensions mimicking in vivo conditions. These advanced in vitro models retain physiologically reliant exposure scenarios particularly appropriate for oral, dermal, respiratory, and intravenous administration of nanomaterials, which have the potential to improve the in vivo predictability and lead to reliable outcomes. In this perspective, we discuss recent developments and breakthroughs in using advanced human in vitro models for hazard assessment of nanomaterials. We identified fit-for-purpose requirements and remaining challenges for the successful implementation of in vitro data into nanomaterials Safe and Sustainable by Design (SSbD), Risk Assessment (RA), and Life Cycle Assessment (LCA). By addressing the gap between in vitro data generation and the utility of in vitro data for nanomaterial safety assessments, a prerequisite for SSbD approaches, we outlined potential key areas for future development.
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来源期刊
NanoImpact
NanoImpact Social Sciences-Safety Research
CiteScore
11.00
自引率
6.10%
发文量
69
审稿时长
23 days
期刊介绍: NanoImpact is a multidisciplinary journal that focuses on nanosafety research and areas related to the impacts of manufactured nanomaterials on human and environmental systems and the behavior of nanomaterials in these systems.
期刊最新文献
Biodistribution and toxic potential of silver nanoparticles when introduced to the female rat reproductive tract A multi-omics approach reveals differences in toxicity and mechanisms in rice (Oryza sativa L.) exposed to anatase or rutile TiO2 nanoparticles Bridging the gap: Innovative human-based in vitro approaches for nanomaterials hazard assessment and their role in safe and sustainable by design, risk assessment, and life cycle assessment Response to shock load of titanium dioxide nanoparticles on aerobic granular sludge and algal-bacterial granular sludge processes Gut-lung microbiota dynamics in mice exposed to Nanoplastics
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