{"title":"从 Ochrocarpus longifolius 的干燥花蕾中提取的七种未曾描述过的化合物。","authors":"","doi":"10.1016/j.phytochem.2024.114307","DOIUrl":null,"url":null,"abstract":"<div><div>Seven unreported compounds were isolated from dried flower buds of <em>Ochrocarpus longifolius</em> in this study, including an alkaloid ochrocaracid A (<strong>1</strong>), five coumarins ochrocarpins I (<strong>2</strong>), J (<strong>3</strong>), K (<strong>4</strong>), L (<strong>5</strong>), and M (<strong>6</strong>), and one styryl-2-pyranone compound iresinoacid (<strong>7</strong>) and nine known compounds (<strong>8</strong>–<strong>16</strong>). All these compounds were found in <em>O. longifolius</em> for the first time. Their structural elucidation was achieved through NMR, HR-ESI-MS, and ECD data. Additionally, a glucose uptake-promoting activity assay revealed that compounds <strong>10</strong> (128.21 μM) and <strong>16</strong> (123.15 μM) increased the glucose uptake capacity of L6 cells by 1.49-fold and 1.48-fold, respectively. These bioactive compounds could be potential candidates for further pharmaceutical applications.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Seven undescribed compounds from dried flower buds of Ochrocarpus longifolius\",\"authors\":\"\",\"doi\":\"10.1016/j.phytochem.2024.114307\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Seven unreported compounds were isolated from dried flower buds of <em>Ochrocarpus longifolius</em> in this study, including an alkaloid ochrocaracid A (<strong>1</strong>), five coumarins ochrocarpins I (<strong>2</strong>), J (<strong>3</strong>), K (<strong>4</strong>), L (<strong>5</strong>), and M (<strong>6</strong>), and one styryl-2-pyranone compound iresinoacid (<strong>7</strong>) and nine known compounds (<strong>8</strong>–<strong>16</strong>). All these compounds were found in <em>O. longifolius</em> for the first time. Their structural elucidation was achieved through NMR, HR-ESI-MS, and ECD data. Additionally, a glucose uptake-promoting activity assay revealed that compounds <strong>10</strong> (128.21 μM) and <strong>16</strong> (123.15 μM) increased the glucose uptake capacity of L6 cells by 1.49-fold and 1.48-fold, respectively. These bioactive compounds could be potential candidates for further pharmaceutical applications.</div></div>\",\"PeriodicalId\":20170,\"journal\":{\"name\":\"Phytochemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031942224003443\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942224003443","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
本研究从 Ochrocarpus longifolius 的干燥花蕾中分离出了七种未报道的化合物，包括一种生物碱 ochrocaracid A (1)，五种香豆素 ochrocarpins I (2)、J (3)、K (4)、L (5) 和 M (6)，一种苯乙烯基-2-吡喃酮化合物 iresinoacid (7) 以及九种已知化合物 (8-16)。所有这些化合物都是首次在 O. longifolius 中发现。通过 NMR、HR-ESI-MS 和 ECD 数据，这些化合物的结构得以阐明。此外，葡萄糖摄取促进活性测定显示，化合物 10（128.21 μM）和 16（123.15 μM）分别将 L6 细胞的葡萄糖摄取能力提高了 1.49 倍和 1.48 倍。这些生物活性化合物可能成为进一步的药物应用候选化合物。
Seven undescribed compounds from dried flower buds of Ochrocarpus longifolius
Seven unreported compounds were isolated from dried flower buds of Ochrocarpus longifolius in this study, including an alkaloid ochrocaracid A (1), five coumarins ochrocarpins I (2), J (3), K (4), L (5), and M (6), and one styryl-2-pyranone compound iresinoacid (7) and nine known compounds (8–16). All these compounds were found in O. longifolius for the first time. Their structural elucidation was achieved through NMR, HR-ESI-MS, and ECD data. Additionally, a glucose uptake-promoting activity assay revealed that compounds 10 (128.21 μM) and 16 (123.15 μM) increased the glucose uptake capacity of L6 cells by 1.49-fold and 1.48-fold, respectively. These bioactive compounds could be potential candidates for further pharmaceutical applications.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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