Physivitrins I-R，从真菌 Physisporinus vitreus 中提取的具有抗炎活性的羊角甾烷三萜类化合物。

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Phytochemistry Pub Date : 2024-10-22 DOI:10.1016/j.phytochem.2024.114314

Fang-Lu Wei , Hui Liu , Shu-Han Zhang , Jiao-Xian Du , Tao Feng , Juan He

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引用次数: 0

摘要

通过对真菌 Physisporinus vitreus 的水稻发酵进行化学研究，分离出了 10 种以前未曾描述过的羊角甾烷三萜类化合物 Physivitrins I-R 和 3 种已知的类似物。这些新结构是在广泛的光谱方法（包括一维和二维核磁共振、HRESIMS、紫外光谱和电离辐射光谱）基础上阐明的。Physivitrins I 和 P 对 LPS 激活的 RAW267.4 巨噬细胞产生的 NO 具有显著的抑制活性，IC50 值分别为 8.2 和 11.5 μM。综合数据表明，玻璃酸浆富含羊毛甾烷三萜类化合物，具有潜在的抗炎应用前景。

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Physivitrins I–R, lanostane triterpenoids with anti-inflammatory activities from the fungus Physisporinus vitreus

Chemical investigation on the rice fermentation of the fungus Physisporinus vitreus led to the isolation of ten previously undescribed lanostane triterpenoids, physivitrins I–R, and three known analogues. The new structures were elucidated on the basis of extensive spectroscopic methods, including 1D & 2D NMR, HRESIMS, UV and ECD. Physivitrins I and P exhibited significant inhibitory activities against NO production in LPS-activated RAW267.4 macrophages with IC₅₀ values of 8.2 and 11.5 μM, respectively. The comprehensive data indicated that P. vitreus is rich in lanostane triterpenes and has potential anti-inflammatory application prospects.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.

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