钻井泥浆急性毒性评估实验研究。

IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Toxics Pub Date : 2024-09-27 DOI:10.3390/toxics12100700
Arstan Mamyrbayev, Saule Bermagambetova, Kuanysh Baytenov, Zhanat Komekbay, Laura Sakebayeva, Umit Satybaldiyeva, Gulmira Yerimbetova, Kulyash Zhilisbayeva
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引用次数: 0

摘要

目前,石油生产的主要技术阶段与钻井作业有关,需要使用种类繁多的钻井泥浆,而钻井泥浆的化学成分复杂多样。所使用的钻井泥浆及其产生的钻井废物必须对人类健康和环境安全。目前,人们对钻井泥浆的毒性和危害仍是一个不甚了解的科学问题,需要从毒理学角度进行详细的研究。钻井泥浆的真正危害和毒性程度只能通过实验方法来确定,因为它的成分会随着工艺性质和损耗程度的变化而变化,并不是一成不变的,这就会改变其毒理学特性。在对成年雄性大鼠进行的一次钻井泥浆胃内注射实验中,获得了有关钻井泥浆毒性和危害参数的新数据。通过使用多种方法(包括 probit 分析方法)确定钻井泥浆的致死剂量,不仅证实了钻井泥浆的平均致死剂量,还证实了毒性的其他参数和实验组动物的存活率。进食行为和体重动态特征以及站立次数和持续时间、梳理频率和持续时间所显示的行为反应性质也表明存在剂量依赖效应。
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Experimental Investigations of Assessment of Acute Toxicity of Drilling Mud.

At present, the main technological stages of oil production related to drilling operations require the use of a wide variety of drilling mud, which has a complex, multicomponent chemical composition. The drilling mud used and the resulting drilling waste must be safe for human health and the environment. The toxicity and hazard of drilling mud at this point in time remain poorly understood scientific problems and require detailing and studying in toxicological terms. The real degree of hazard and toxicity of drilling mud can only be determined by an experimental method, since its composition, which changes depending on the nature of the technological process and its degree of depletion, is not constant, which can change the toxicological properties. In an experiment conducted on adult male rats, under conditions of a single intragastric injection of drilling mud, new data were obtained regarding the parameters of its toxicity and hazard. The use of a wide variety of methods for determining lethal doses of drilling mud, including the probit analysis method, made it possible not only to substantiate the mean lethal dose of drilling mud but also other parameters of toxicity and survival of animals in the experimental groups. Features of eating behavior and body weight dynamics and the nature of the behavioral reactions revealed by the number and duration of stands and frequency and duration of grooming also indicate the presence of dose-dependent effects.

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来源期刊
Toxics
Toxics Chemical Engineering-Chemical Health and Safety
CiteScore
4.50
自引率
10.90%
发文量
681
审稿时长
6 weeks
期刊介绍: The Journal accepts papers describing work that furthers our understanding of the exposure, effects, and risks of chemicals and materials in humans and the natural environment as well as approaches to assess and/or manage the toxicological and ecotoxicological risks of chemicals and materials. The journal covers a wide range of toxic substances, including metals, pesticides, pharmaceuticals, biocides, nanomaterials, and polymers such as micro- and mesoplastics. Toxics accepts papers covering: The occurrence, transport, and fate of chemicals and materials in different systems (e.g., food, air, water, soil); Exposure of humans and the environment to toxic chemicals and materials as well as modelling and experimental approaches for characterizing the exposure in, e.g., water, air, soil, food, and consumer products; Uptake, metabolism, and effects of chemicals and materials in a wide range of systems including in-vitro toxicological assays, aquatic and terrestrial organisms and ecosystems, model mammalian systems, and humans; Approaches to assess the risks of chemicals and materials to humans and the environment; Methodologies to eliminate or reduce the exposure of humans and the environment to toxic chemicals and materials.
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