Hoonsung Choi, Kyungho Ha, Jin Taek Kim, Min Kyong Moon, Hyojee Joung, Hong Kyu Lee, Youngmi Kim Pak
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引用次数: 0
摘要
线粒体功能障碍与肥胖和糖尿病密切相关,老年肺功能下降会增加糖尿病风险,这可能是由于长期暴露于环境污染物导致血清中二恶英类线粒体抑制物质(MIS)水平升高所致。然而,线粒体抑制物质、线粒体、肺功能和代谢紊乱之间的关联机制仍不清楚。在这项研究中,我们分析了 2008 年韩国基因组流行病学研究(KoGES)安城队列中 1371 名 40-69 岁成年人的数据。我们通过测量用参与者血清处理过的培养细胞中的细胞内 ATP(MISATP)和活性氧(MISROS),间接估计了二恶英类 MIS 的水平。通过相关分析和结构方程模型(SEM),我们探讨了 MIS、线粒体功能、体重指数(BMI)和肺功能(FEV1 和 FVC)之间的关系。我们的研究结果表明,MISATP 与女性的体重指数和男性的肺活量相关,而 MISROS 与男性的体重指数和肺活量相关,但与女性无关。在 MIS 值最高的亚组中,男女均发现 BMI 和 FVC 之间存在显著关联。SEM 分析表明,MIS 对线粒体功能有负面影响,而线粒体功能又会影响体重指数和肺功能。与年龄相关的肺功能下降也与线粒体功能障碍有关。这项研究强调了 MIS 检测作为线粒体功能评估替代方法的潜力,并突出了线粒体健康在代谢紊乱和肺功能中的重要性。
Relationships among Dioxin-like Mitochondria Inhibitor Substances (MIS)-Mediated Mitochondria Dysfunction, Obesity, and Lung Function in a Korean Cohort.
Mitochondrial dysfunction is closely linked to obesity and diabetes, with declining lung function in aging increasing diabetes risk, potentially due to elevated serum levels of dioxin-like mitochondria inhibitor substances (MIS) from prolonged exposure to environmental pollutants. However, the mechanisms connecting MIS, mitochondria, lung function, and metabolic disorder remain unclear. In this study, we analyzed data from 1371 adults aged 40-69 years in the 2008 Korean Genome Epidemiologic Study (KoGES) Ansung cohort. We indirectly estimated dioxin-like MIS levels by measuring intracellular ATP (MISATP) and reactive oxygen species (MISROS) in cultured cells treated with the serum of participants. Using correlation analysis and structural equation modeling (SEM), we explored the relationships among MIS, mitochondrial function, body mass index (BMI), and lung function (FEV1 and FVC). Our findings revealed that MISATP was associated with BMI in females and with FVC in males, while MISROS correlated with both BMI and FVC in males, not in females. Significant associations between BMI and FVC were found in the highest MIS subgroup in both sexes. SEM analyses demonstrated that MIS negatively influenced mitochondrial function, which in turn affected BMI and lung function. Age-related declines in lung function were also linked to mitochondrial dysfunction. This study underscores the potential of MIS assays as alternatives for assessing mitochondrial function and highlights the importance of mitochondrial health in metabolic disorders and lung function.
ToxicsChemical Engineering-Chemical Health and Safety
CiteScore
4.50
自引率
10.90%
发文量
681
审稿时长
6 weeks
期刊介绍:
The Journal accepts papers describing work that furthers our understanding of the exposure, effects, and risks of chemicals and materials in humans and the natural environment as well as approaches to assess and/or manage the toxicological and ecotoxicological risks of chemicals and materials. The journal covers a wide range of toxic substances, including metals, pesticides, pharmaceuticals, biocides, nanomaterials, and polymers such as micro- and mesoplastics. Toxics accepts papers covering:
The occurrence, transport, and fate of chemicals and materials in different systems (e.g., food, air, water, soil);
Exposure of humans and the environment to toxic chemicals and materials as well as modelling and experimental approaches for characterizing the exposure in, e.g., water, air, soil, food, and consumer products;
Uptake, metabolism, and effects of chemicals and materials in a wide range of systems including in-vitro toxicological assays, aquatic and terrestrial organisms and ecosystems, model mammalian systems, and humans;
Approaches to assess the risks of chemicals and materials to humans and the environment;
Methodologies to eliminate or reduce the exposure of humans and the environment to toxic chemicals and materials.