2,2',4,4'-四溴二苯醚（BDE-47）对海洋生物的毒理效应和机制。

IF 4.9 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Toxics Pub Date : 2024-10-15 DOI:10.3390/toxics12100747

Boyang Li, Yun Shao, Chen Liu, Jie Wang, Yanzhong Zhu, Xiaoqian Li

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引用次数: 0

摘要

2,2',4,4'-四溴二苯醚（BDE-47）是一种广泛使用的溴化阻燃剂，属于持久性有机污染物（POPs）。BDE-47 释放到海洋环境中后，可通过生物累积、生物放大和代际传播对海洋生物造成一系列毒性影响。这些效应包括致死、运动能力受损、光合毒性、免疫损伤、肝脏毒性、发育障碍和生殖毒性。本文回顾了有关上述 BDE-47 毒性效应和分子机制的最新研究进展。其毒性的主要机制包括氧化应激、DNA 损伤、细胞凋亡、新陈代谢受损和激活 MAPK 信号级联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Toxicological Effects and Mechanisms of 2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) on Marine Organisms.

2,2',4,4'-tetrabromodiphenyl ether (BDE-47) is a widely used brominated flame retardant belonging to persistent organic pollutants (POPs). After being released into the marine environment, BDE-47 can cause a range of toxic effects on marine organisms through bioaccumulation, biomagnification, and intergenerational transmission. These effects include lethality, impaired motility, photosynthetic toxicity, immune damage, liver toxicity, developmental impairments, and reproductive toxicity. This article reviews the latest research progress on the toxic effects and molecular mechanisms of BDE-47 mentioned above. The primary mechanisms underlying its toxicity include oxidative stress, DNA damage, cellular apoptosis, impaired metabolism, and activation of the MAPK signaling cascade.

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来源期刊

Toxics Chemical Engineering-Chemical Health and Safety

CiteScore

4.50

自引率

10.90%

发文量

681

审稿时长

6 weeks

期刊介绍： Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.