刺激剂和抗精神病药物对注意力缺陷多动障碍儿童进食行为和体重的比较效应》(Comparative Effects of Stimulant and Antipsychotic Medications on Eating Behaviors and Weight in Children with Attention Deficit Hyperactivity Disorder)。

IF 2 4区 医学 Q2 PEDIATRICS Children-Basel Pub Date : 2024-09-28 DOI:10.3390/children11101189
Hasan Cem Aykutlu, Esra Okyar, Mehmet Karadağ, Masum Öztürk
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引用次数: 0

摘要

背景/目的:注意力缺陷/多动障碍(ADHD)与肥胖和饮食行为紊乱的风险增加有关。本研究比较了未经药物治疗的ADHD儿童、接受刺激剂单一疗法的儿童、接受刺激剂和抗精神病药物联合疗法的儿童以及健康对照组儿童的体重状况和饮食行为:这项横断面研究包括来自土耳其四个省的 547 名 6-12 岁儿童:361名患有多动症的儿童(152名未接受过药物治疗,156名接受过兴奋剂治疗,53名接受过联合治疗)和186名健康对照组儿童。研究人员使用标准化工具进行了人体测量、精神评估和饮食行为评估:与对照组相比,未接受药物治疗的多动症儿童肥胖率最高(13.8%),而接受刺激剂单一疗法的儿童肥胖率最低(4.5%)。联合治疗组的肥胖率与对照组相似(7.5% 对 8.6%)。未服药组和联合治疗组的食物接近行为和饮酒欲望增加,联合治疗组的情绪性暴饮暴食也有所增加:本研究揭示了多动症、药物治疗与肥胖风险之间的复杂关系。结论:本研究揭示了多动症、其药物治疗与肥胖风险之间的复杂关系。单一刺激剂治疗可减轻肥胖风险,而刺激剂和抗精神病药物联合治疗则可能导致有问题的饮食行为。这些发现强调了监测多动症儿童体重状况和饮食行为的重要性,尤其是那些接受药物干预的儿童。
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Comparative Effects of Stimulant and Antipsychotic Medications on Eating Behaviors and Weight in Children with Attention Deficit Hyperactivity Disorder.

Background/objectives: Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with an increased risk of obesity and disordered eating behaviors. This study compared weight status and eating behaviors among drug-naïve ADHD children, those on stimulant monotherapy, those on combined stimulant and antipsychotic treatment, and healthy controls.

Methods: This cross-sectional study included 547 children aged 6-12 years from four Turkish provinces: 361 with ADHD (152 drug-naïve, 156 on stimulants, and 53 on combined therapy), and 186 healthy controls. Anthropometric measurements, psychiatric assessments, and eating behavior evaluations were conducted using standardized tools.

Results: Drug-naïve ADHD children had the highest obesity rate (13.8%), while those on stimulant monotherapy had the lowest (4.5%) compared to controls. Combined treatment group obesity rates were similar to controls (7.5% vs. 8.6%). The drug-naïve and combined treatment groups showed increased food approach behavior and desire to drink, with the combined treatment group also showing increased emotional overeating.

Conclusions: This study reveals a complex relationship between ADHD, its pharmacological management, and the risk of obesity. Stimulant monotherapy may mitigate the risk of obesity, while combined stimulant and antipsychotic treatment may lead to problematic eating behaviors. These findings emphasize the importance of monitoring weight status and eating behaviors in ADHD children, especially those receiving pharmacological interventions.

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来源期刊
Children-Basel
Children-Basel PEDIATRICS-
CiteScore
2.70
自引率
16.70%
发文量
1735
审稿时长
6 weeks
期刊介绍: Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.
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