拟南芥 mRNA ADENOSINE METHYLASE 通过 N6-甲基腺苷对 mRNA 调控的依赖和独立影响促进抗旱性。

IF 8.1 1区 生物学 Q1 PLANT SCIENCES New Phytologist Pub Date : 2024-10-27 DOI:10.1111/nph.20227
Diep R. Ganguly, Yongfang Li, Susheel Sagar Bhat, Shalini Tiwari, Pei Jia Ng, Brian D. Gregory, Ramanjulu Sunkar
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引用次数: 0

摘要

在许多 mRNA 修饰中，已知 N6 位腺嘌呤甲基化（N6-甲基腺苷，m6A）会广泛影响 mRNA 的生物学特性。在干旱这种影响最大的非生物胁迫下，m6A 的影响还有待评估。我们的研究表明，拟南芥（Arabidopsis thaliana (L.) Heynh.(拟南芥）缺乏mRNA腺苷甲酰酶（MTA）的植株对干旱敏感。随后，我们全面评估了干旱期间 MTA 依赖性 m6A 变化对拟南芥 mRNA 丰度、稳定性和翻译的影响。在干旱期间，许多蛋白质编码转录本出现了全球性的高甲基化趋势，而这在 mta 中并不发生。我们还观察到 m6A 在转录本特异性水平上的复杂调控，这可能反映了其他 m6A 成分的补偿作用。重要的是，在干旱期间，与野生型（WT）植物相比，以 MTA 依赖性方式发生高甲基化的转录本子集在 mta 中的转换和翻译都有所减少。此外，MTA 对转录本稳定性和翻译的影响与 m6A 无关。我们还发现，与干旱相关的 m6A 沉积与干旱响应调节因子（如 WT 中的 RD29A、COR47、COR413、ALDH2B、ERD7 和 ABF4）的翻译增加有关，而这在 mta 中会受到影响。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

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mRNA ADENOSINE METHYLASE promotes drought tolerance through N6-methyladenosine-dependent and independent impacts on mRNA regulation in Arabidopsis

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来源期刊
New Phytologist
New Phytologist 生物-植物科学
自引率
5.30%
发文量
728
期刊介绍： New Phytologist is an international electronic journal published 24 times a year. It is owned by the New Phytologist Foundation, a non-profit-making charitable organization dedicated to promoting plant science. The journal publishes excellent, novel, rigorous, and timely research and scholarship in plant science and its applications. The articles cover topics in five sections: Physiology & Development, Environment, Interaction, Evolution, and Transformative Plant Biotechnology. These sections encompass intracellular processes, global environmental change, and encourage cross-disciplinary approaches. The journal recognizes the use of techniques from molecular and cell biology, functional genomics, modeling, and system-based approaches in plant science. Abstracting and Indexing Information for New Phytologist includes Academic Search, AgBiotech News & Information, Agroforestry Abstracts, Biochemistry & Biophysics Citation Index, Botanical Pesticides, CAB Abstracts®, Environment Index, Global Health, and Plant Breeding Abstracts, and others.
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