Martin Horn, Lucia Bieliková, Andrea Vostoupalová, Jakub Švéda, Michael Mareš
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An update on proteases and protease inhibitors from trematodes.
Trematodes, a class of parasitic flatworms, are responsible for a variety of devastating diseases in humans and animals, with schistosomiasis and fascioliasis being prominent examples. Trematode proteolytic systems involved in the host-parasite interaction have emerged as key contributors to the success of trematodes in establishing and maintaining infections. This review concentrates on diverse proteases and protease inhibitors employed by trematodes and provides an update on recent advances in their molecular-level characterization, with a focus on function, structure, and therapeutic target potential.
期刊介绍：
Advances in Parasitology is recognised as a leading review serial which is consistently well placed in terms of impact factor and citations. Major reviews on all aspects of medical, veterinary and wild-life parasitology are considered. The journal provides an outlet for authoritative reviews from experts in the field. While emphasis is given to modern molecular approaches contributions across all disciplines are encouraged including traditional areas such as ecology and taxonomy. Eclectic volumes are supplemented by thematic volumes dedicated to a particular topic of recognised interest and importance.
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