抑制非编码翻译的机制

IF 13 1区 生物学 Q1 CELL BIOLOGY Trends in Cell Biology Pub Date : 2024-10-22 DOI:10.1016/j.tcb.2024.09.004
Jordan S Kesner, Xuebing Wu
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引用次数: 0

摘要

我们基因组中的大部分 DNA 序列都是非编码序列,并非用于合成蛋白质。然而,核糖体足迹的全基因组图谱显示,已注释的非编码序列中存在广泛的翻译,包括长非编码 RNA(lncRNA)、非翻译区(UTR)和 mRNA 的内含子。细胞如何抑制来自各种非编码序列的潜在毒性蛋白质的翻译,目前仍鲜为人知。这篇综述总结了非编码翻译的缓解机制,包括 BCL2 相关athanogene 6 (BAG6) 介导的蛋白酶体降解途径,该途径已成为元动物细胞中抑制各种非编码序列翻译的统一机制。
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Mechanisms suppressing noncoding translation.

The majority of the DNA sequence in our genome is noncoding and not intended for synthesizing proteins. Nonetheless, genome-wide mapping of ribosome footprints has revealed widespread translation in annotated noncoding sequences, including long noncoding RNAs (lncRNAs), untranslated regions (UTRs), and introns of mRNAs. How cells suppress the translation of potentially toxic proteins from various noncoding sequences remains poorly understood. This review summarizes mechanisms for the mitigation of noncoding translation, including the BCL2-associated athanogene 6 (BAG6)-mediated proteasomal degradation pathway, which has emerged as a unifying mechanism to suppress the translation of diverse noncoding sequences in metazoan cells.

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来源期刊
Trends in Cell Biology
Trends in Cell Biology 生物-细胞生物学
CiteScore
32.00
自引率
0.50%
发文量
160
审稿时长
61 days
期刊介绍: Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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