巩膜镜对角膜异位症患者视力和眼球失常的影响:全面综述。

IF 3 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Journal of Personalized Medicine Pub Date : 2024-10-11 DOI:10.3390/jpm14101051
Vincenzo Barone, Daniele Petrini, Sebastiano Nunziata, Pier Luigi Surico, Claudia Scarani, Francesco Offi, Valentina Villani, Marco Coassin, Antonio Di Zazzo
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引用次数: 0

摘要

角膜异位症,包括角膜炎(KC)、透明边缘变性(PMD)和激光角膜屈光手术(LASIK)后角膜异位症,会导致不规则散光、近视和高阶像差(HOA),给视觉康复带来巨大挑战。这些情况通常无法通过传统的矫正方法来解决,因此需要先进的光学解决方案。巩膜透镜(SL)已成为控制这些复杂角膜不规则情况的主要非手术选择。巩膜塑形镜通过在镜片和角膜之间形成一个充满泪液的腔体,形成一个平滑的光学界面,从而有效减轻HOA,提高高对比度和低对比度视力(VA)。本综述评估了角膜塑形镜在提高角膜异位症患者的视力和减少像差方面的功效。它还探讨了角膜塑形镜的技术进步,如轮廓测量和波前引导系统,这些系统通过精确测量眼球表面和解决特定的视像差问题,实现了更精确和定制化的镜片装配。目前的大量证据表明,定制的人工晶体能显著改善各种异位情况下的视觉效果,与传统的矫正方法相比性能更优越。然而,验配的复杂性和精确配准的必要性等挑战依然存在。角膜塑形镜技术和定制方面的不断创新可能会进一步提高其临床实用性,从而巩固其作为角膜异位症治疗中不可或缺的工具的地位。
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Impact of Scleral Lenses on Visual Acuity and Ocular Aberrations in Corneal Ectasia: A Comprehensive Review.

Corneal ectasias, including keratoconus (KC), pellucid marginal degeneration (PMD), and post-LASIK ectasia, poses significant visual rehabilitation challenges due to the resultant irregular astigmatism, myopia, and higher-order aberrations (HOAs). These conditions often resist traditional corrective methods, necessitating advanced optical solutions. Scleral lenses (SLs) have emerged as a primary non-surgical option for managing these complex corneal irregularities. SLs form a smooth optical interface by forming a tear-filled chamber between the lens and the cornea, effectively mitigating HOAs and improving both high-contrast and low-contrast visual acuity (VA). This review evaluates the efficacy of SLs in enhancing VA and reducing aberrations in patients with corneal ectasia. It also explores the technological advancements in SLs, such as profilometry and wavefront-guided systems, which enable more precise and customized lens fittings by accurately mapping the eye's surface and addressing specific visual aberrations. The current body of evidence demonstrates that custom SLs significantly improve visual outcomes across various ectatic conditions, offering superior performance compared to conventional correction methods. However, challenges such as the complexity of fitting and the need for precise alignment remain. Ongoing innovations in SL technology and customization are likely to further enhance their clinical utility, solidifying their role as an indispensable tool in the management of corneal ectasias.

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来源期刊
Journal of Personalized Medicine
Journal of Personalized Medicine Medicine-Medicine (miscellaneous)
CiteScore
4.10
自引率
0.00%
发文量
1878
审稿时长
11 weeks
期刊介绍: Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.
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