非法药物检测的演变:从传统方法到尖端免疫传感器--全面回顾。

IF 4.9 3区 工程技术 Q1 CHEMISTRY, ANALYTICAL Biosensors-Basel Pub Date : 2024-10-03 DOI:10.3390/bios14100477
Nigar Anzar, Shariq Suleman, Yashda Singh, Supriya Kumari, Suhel Parvez, Roberto Pilloton, Jagriti Narang
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引用次数: 0

摘要

非法药物的使用日益增多已成为全球关注的一个主要问题。非法药物会与大脑和身体相互作用,改变人的情绪和行为。随着滥用药物(SOA)危机继续在全球蔓延,为了减少贩运和非法活动,使用生物传感器等护理点设备非常重要。目前,用于检测滥用药物的传统检测方法有气相色谱法(GC)、质谱法(MS)、表面电离法、表面增强拉曼光谱法(SERS)、表面等离子体共振法(SPR)、电化学发光法(ECL)、高效液相色谱法(HPLC)等。这些方法具有准确度和灵敏度高的优点,但一般都比较费力、昂贵,需要经过培训的操作人员,而且对样品的要求较高,不适合现场毒品检测的情况。因此,人们迫切需要能够替代传统技术的各种药物护理点技术,如生物传感器,特别是免疫传感器。免疫传感器是一种分析设备,它将基于抗体的识别元件与传感器集成在一起,用于检测特定分子(抗原)。在免疫传感器中,高度选择性的抗原-抗体相互作用被用来识别和量化目标分析物。抗体和抗原之间的结合事件被传感器转换成可测量的信号,如电信号、光学信号或电化学信号,这些信号与样品中分析物的存在和浓度相对应。本文全面概述了各种非法药物、检测非法药物的传统方法以及免疫传感器相对于传统技术的优势。它强调了现场检测的迫切需要,并探讨了新兴的床旁检测方法。论文还概述了该领域未来的研究目标,强调了先进技术在提高毒品检测的准确性、效率和便利性方面的潜力。
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The Evolution of Illicit-Drug Detection: From Conventional Approaches to Cutting-Edge Immunosensors-A Comprehensive Review.

The increasing use of illicit drugs has become a major global concern. Illicit drugs interact with the brain and the body altering an individual's mood and behavior. As the substance-of-abuse (SOA) crisis continues to spread across the world, in order to reduce trafficking and unlawful activity, it is important to use point-of-care devices like biosensors. Currently, there are certain conventional detection methods, which include gas chromatography (GC), mass spectrometry (MS), surface ionization, surface-enhanced Raman spectroscopy (SERS), surface plasmon resonance (SPR), electrochemiluminescence (ECL), high-performance liquid chromatography (HPLC), etc., for the detection of abused drugs. These methods have the advantage of high accuracy and sensitivity but are generally laborious, expensive, and require trained operators, along with high sample requirements, and they are not suitable for on-site drug detection scenarios. As a result, there is an urgent need for point-of-care technologies for a variety of drugs that can replace conventional techniques, such as a biosensor, specifically an immunosensor. An immunosensor is an analytical device that integrates an antibody-based recognition element with a transducer to detect specific molecules (antigens). In an immunosensor, the highly selective antigen-antibody interaction is used to identify and quantify the target analyte. The binding event between the antibody and antigen is converted by the transducer into a measurable signal, such as electrical, optical, or electrochemical, which corresponds to the presence and concentration of the analyte in the sample. This paper provides a comprehensive overview of various illicit drugs, the conventional methods employed for their detection, and the advantages of immunosensors over conventional techniques. It highlights the critical need for on-site detection and explores emerging point-of-care testing methods. The paper also outlines future research goals in this field, emphasizing the potential of advanced technologies to enhance the accuracy, efficiency, and convenience of drug detection.

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来源期刊
Biosensors-Basel
Biosensors-Basel Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
6.60
自引率
14.80%
发文量
983
审稿时长
11 weeks
期刊介绍: Biosensors (ISSN 2079-6374) provides an advanced forum for studies related to the science and technology of biosensors and biosensing. It publishes original research papers, comprehensive reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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