电纺壳聚糖/聚醚砜纳米纤维作为治疗小鼠糖尿病烧伤创面敷料的潜在创面敷料的体内生物相容性

IF 2.2 4区 化学 Q2 Engineering Chemical Papers Pub Date : 2024-10-04 DOI:10.1007/s11696-024-03714-w
Farhin Khan, Baishakhi Bairagi, Bidya Mondal, Dipankar Mandal, Debjani Nath
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引用次数: 0

摘要

糖尿病是当今时代生活方式的一大灾难,患者会患上各种并发症。由于感染率高,糖尿病烧伤创面患者大多会合并其他疾病。我们的研究重点是使用壳聚糖/聚环氧乙烷(CS/PEO)的独特组合,通过电纺丝将其编织成纤维,以缓解这些严重的健康状况。壳聚糖的抗炎、抗菌和组织修复功效以及聚环氧乙烷的广谱抗菌作用在治疗异位感染和组织再上皮化方面得到了突显。为了研究 CS/PEO 纳米纤维作为敷料在烧伤创面上的适用性,研究人员建立了单剂量链脲佐菌素诱导的糖尿病小鼠模型。纳米纤维的平均直径为 165 nm,模拟细胞外基质,具有显著的溶胀度(125%)和热稳定性。对伤口中细菌种类的光密度研究表明,其抗菌活性超过 50%。对糖尿病小鼠进行的平面评估、血红素和伊红染色(HE)以及马森三色染色(MT)表明,20 天内伤口收缩率达到 94.7%(p <0.01),伤口重新上皮化的趋势不断增强,炎症发生率降低。因此,CS/PEO 纳米纤维可作为一种极佳的替代敷料材料,通过限制炎症浸润和微血管以及抗菌功效来愈合糖尿病烧伤创面。
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In vivo biocompatibility of electrospun chitosan/PEO nanofiber as potential wound dressing material for diabetic burn wound injury of mice

Diabetes is a lifestyle havoc of the present epoch and patients suffer from all co-morbid situations. Diabetic burn wound patients are mostly affected due to the high rate of infection-alluring co-morbidity. Our study focused on the use of a unique combination of Chitosan/Polyethylene oxide (CS/PEO) woven into fibers by electrospinning to relieve these critical health conditions. The anti-inflammatory, antibacterial and tissue-repairing virtue of chitosan along with the broad-spectrum antibacterial effect of polyethylene oxide were highlighted for the treatment of ectopic infection and re-epithelialization of tissue. Single-dose streptozotocin-induced diabetic mice model was developed to study the applicability of CS/PEO nanofiber as dressing material on burn wounds. The average nanofiber diameter was 165  nm mimicking the extracellular matrix with a significant degree (125%) of swelling and thermal stability. Studies of optical density on the bacterial species identified from the wound suggested more than 50% antibacterial activity. Planimetric assessment, Haematoxylin & Eosin staining (HE) and Masson’s Trichrome (MT) staining suggested a remarkable 94.7% (p < 0.01) wound contraction with the increasing trend of re-epithelialization and  a reduced rate of inflammation in diabetic mice over 20 days. So, CS/PEO nanofiber can be used as an excellent alternative dressing material to heal diabetic burn wounds by limiting inflammatory infiltration and microvessels along with antibacterial efficacy.

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来源期刊
Chemical Papers
Chemical Papers Chemical Engineering-General Chemical Engineering
CiteScore
3.30
自引率
4.50%
发文量
590
期刊介绍: Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.
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