聚（2-乙烯基吡啶）磁铁矿纳米颗粒用于 5-氟尿嘧啶靶向递送：合成、吸收和释放研究

IF 2.2 4区化学 Q2 Engineering Chemical Papers Pub Date : 2024-09-25 DOI:10.1007/s11696-024-03680-3

I. V. Korolkov, K. A. Izbasar, Zh. A. Bekbol, A. V. Zibert, A. E. Shumskaya, L. I. Lissovskaya, L. N. Korganbayeva, M. V. Zdorovets

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引用次数: 0

摘要

抗癌药物的主要局限性之一是选择性差和毒性大。本研究旨在通过开发靶向给药系统来克服这些困难。研究人员以磁铁矿纳米颗粒为基础，用 3-(三甲氧基硅基)丙基甲基丙烯酸酯对其表面进行预修饰，合成了接枝聚(2-乙烯基吡啶)的给药系统。傅立叶变换红外光谱法、X 射线衍射法、振动样品磁力测定法、能量色散 X 射线分析法和热重分析法检测了合成样品的物理和化学特性。通过 DLS 测定了纳米粒子的尺寸，最终的 Fe3O4-TMSPM-P2VP-5FU 纳米粒子的平均尺寸为 120 nm（PDI 为 0.286）。在不同的 pH 值（4.5 和 7.58）和 36.6 °C 的恒温条件下，使用紫外可见光谱检测了 5-FU 的释放情况。

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Poly(2-vinylpyridine) magnetite nanoparticles for 5-fluorouracil targeted delivery: synthesis, uptake and release study

One of the major limitations of anti-cancer drugs is their poor selectivity and high toxicity. The present study aims to overcome these difficulties by developing targeted drug delivery systems. Drug delivery systems were synthesized based on magnetite nanoparticles with grafted poly(2-vinylpyridine) from their pre-modified surface with 3-(trimethoxysilyl)propyl methacrylate. The physical and chemical properties of synthesized samples were examined by Fourier-transform infrared spectroscopy, X-ray diffraction, vibrating-sample magnetometry, Energy-dispersive X-Ray analysis and thermogravimetric analysis. The size of nanoparticles was estimated by DLS, final Fe₃O₄-TMSPM-P2VP-5FU nanoparticles have an average size of 120 nm (PDI is 0.286). Release of 5-FU was examined at different pH (4.5 and 7.58) and constant temperature of 36.6 °C using UV–Vis spectroscopy.

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来源期刊

Chemical Papers Chemical Engineering-General Chemical Engineering

CiteScore

3.30

自引率

4.50%

发文量

590

期刊介绍： Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.