将丝胶和叶酸碳点嵌入生物衍生聚(乳酸)/丝胶纳米凝胶中的混合纳米材料,并将其与表面多孔的聚(乳酸-共聚乙二醇)电纺纤维结合,以在组织工程和药物输送系统中用作支架的可能性

IF 23.2 2区 材料科学 Q1 MATERIALS SCIENCE, COMPOSITES Advanced Composites and Hybrid Materials Pub Date : 2024-10-25 DOI:10.1007/s42114-024-01040-z
Areeya Tuanchai, Sasimontra Timjan, Nantaprapa Tuancharoensri, Preeyawass Phimnuan, Widsanusan Chartarrayawadee, Patnarin Worajittiphon, Yujia Liu, Gareth Michael Ross, Céline Viennet, Jarupa Viyoch, Huan-Tsung Chang, Masafumi Unno, Sukunya Ross
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引用次数: 0

摘要

研究人员开发了由碳点(CD)、纳米凝胶和电纺纳米纤维组成的混合纳米材料,用于组织工程和药物输送。研究人员使用蚕丝丝胶(CDSS)和蚕丝丝胶与叶酸的混合物(CDSSF)合成了碳点,并在不同条件下通过水热处理对其进行了优化。研究人员进行了广泛的分析,并考察了 CD 的特性,包括形态、荧光、紫外可见吸收、官能团、尺寸、ZETA 电位和 pH 依赖性药物释放 (RhB)。CDSS 和 CDSSF 都被整合到生物衍生的聚乳酸/丝胶丝胶纳米凝胶中,并进一步与多孔的聚乳酸-聚乙二醇(PLGA(P))电纺纳米纤维相结合。结果表明,在 220 °C 下合成 6 小时的 CD 具有最佳的荧光(激发波长为 320 纳米和 360 纳米),粒径为 10-30 纳米,Zeta 电位为 - 15.9 至 19.7 mV。嵌入了 CD 的生物衍生纳米凝胶呈球形(30-200 nm),并成功地与 PLGA(P) 纳米纤维结合在一起。这些纳米材料对正常人真皮成纤维细胞(NHDF)无毒性,在划痕试验中可促进伤口在 36 小时内完全愈合。总之,这些设计的电纺纳米纤维结合了生物纳米凝胶和 CD,有望用于组织工程,特别是皮肤组织再生和可控药物释放应用。
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Hybrid nanomaterials of carbon dots of silk sericin and folic acid embedded in bio-derived poly(lactic acid)/silk sericin nanogels and their incorporation with surface-porous electrospun fibers of poly(lactide-co-glycolide) for potential use as scaffolds in tissue engineering and drug delivery system

Hybrid nanomaterials, consisting of carbon dots (CDs), nanogels, and electrospun nanofibers, were developed for tissue engineering and drug delivery. CDs were synthesized using Bombyx mori silk sericin (CDSS) and SS mixed with folic acid (CDSSF) and optimized through hydrothermal treatment under various conditions. Extensive analysis was conducted, and CD properties, including morphology, fluorescence, UV–Vis absorption, functional groups, size, zeta potential, and pH-dependent drug release (RhB), were investigated. Both CDSS and CDSSF were integrated into bio-derived poly(lactic acid)/silk sericin nanogels, which were further combined with porous electrospun nanofibers of poly(lactide-co-glycolide) (PLGA(P)). Results revealed that CDs synthesized at 220 °C for 6 h exhibited optimal fluorescence (excitation at 320 and 360 nm), a particle size of 10–30 nm, and a zeta potential ranging from − 15.9 to 19.7 mV. CDs were composed of approximately 55% C, 23% O, and 22% N. The pH-dependent release of RhB was higher in pH 7.4 than in pH 5.0, with a significant increase within 4 h and stabilization after 8 h. Bio-derived nanogels embedded with CDs demonstrated spherical shapes (30–200 nm) and were successfully integrated with PLGA(P) nanofibers. These nanomaterials were non-cytotoxic to normal human dermal fibroblast (NHDF) cells and promoted complete wound healing in scratch tests within 36 h. In conclusion, these designed electrospun nanofibers, incorporating bio-derived nanogels and CDs, hold promise for tissue engineering, particularly in skin tissue regeneration and controlled drug-release applications.

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来源期刊
CiteScore
26.00
自引率
21.40%
发文量
185
期刊介绍: Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.
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