{"title":"用于便携式 H2O2 床旁检测的基于持久化学发光的纳米传感器","authors":"Yueliang Wang, Xiying Chen, Zhanhui Tao, Jingya Zhou, Hanyue Sun, Xian Li, Liyu Shi, Yaqing Liu","doi":"10.1007/s00604-024-06794-3","DOIUrl":null,"url":null,"abstract":"<div><p> A novel glow-type chemiluminescence (CL)-based nanosensing system was developed for sensitive and rapid point-of-care testing (POCT) of H<sub>2</sub>O<sub>2</sub> in food. CuSe nanoparticles (CuSe<sub>NPs</sub>) have excellent peroxidase-like activity. After being modified with thiols of 4-mercaptophenylboronic acid (MBA) (CuSe<sub>NPs</sub>@MBA), luminol can be catalyzed to produce long-lasting CL in the presence of H<sub>2</sub>O<sub>2</sub>. The possible reason for the long-lasting glow-type CL behavior was explored. Under the optimized condition, H<sub>2</sub>O<sub>2</sub> can be sensitively detected with improved repeatability. The limit of detection is as low as 0.30 μM. To meet the requirement of in situ and outside of laboratory detection, a 3D-printed portable device was designed which can eliminate the environmental interference to improve detection accuracy. The developed multifunctional platform also has the advantages of simple operation and low cost, suggesting its great potential for applications in food and agricultural fields.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 11","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Persistent chemiluminescence-based nanosensor for portable point-of-care testing of H2O2\",\"authors\":\"Yueliang Wang, Xiying Chen, Zhanhui Tao, Jingya Zhou, Hanyue Sun, Xian Li, Liyu Shi, Yaqing Liu\",\"doi\":\"10.1007/s00604-024-06794-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p> A novel glow-type chemiluminescence (CL)-based nanosensing system was developed for sensitive and rapid point-of-care testing (POCT) of H<sub>2</sub>O<sub>2</sub> in food. CuSe nanoparticles (CuSe<sub>NPs</sub>) have excellent peroxidase-like activity. After being modified with thiols of 4-mercaptophenylboronic acid (MBA) (CuSe<sub>NPs</sub>@MBA), luminol can be catalyzed to produce long-lasting CL in the presence of H<sub>2</sub>O<sub>2</sub>. The possible reason for the long-lasting glow-type CL behavior was explored. Under the optimized condition, H<sub>2</sub>O<sub>2</sub> can be sensitively detected with improved repeatability. The limit of detection is as low as 0.30 μM. To meet the requirement of in situ and outside of laboratory detection, a 3D-printed portable device was designed which can eliminate the environmental interference to improve detection accuracy. The developed multifunctional platform also has the advantages of simple operation and low cost, suggesting its great potential for applications in food and agricultural fields.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":705,\"journal\":{\"name\":\"Microchimica Acta\",\"volume\":\"191 11\",\"pages\":\"\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2024-10-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microchimica Acta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00604-024-06794-3\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchimica Acta","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00604-024-06794-3","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Persistent chemiluminescence-based nanosensor for portable point-of-care testing of H2O2
A novel glow-type chemiluminescence (CL)-based nanosensing system was developed for sensitive and rapid point-of-care testing (POCT) of H2O2 in food. CuSe nanoparticles (CuSeNPs) have excellent peroxidase-like activity. After being modified with thiols of 4-mercaptophenylboronic acid (MBA) (CuSeNPs@MBA), luminol can be catalyzed to produce long-lasting CL in the presence of H2O2. The possible reason for the long-lasting glow-type CL behavior was explored. Under the optimized condition, H2O2 can be sensitively detected with improved repeatability. The limit of detection is as low as 0.30 μM. To meet the requirement of in situ and outside of laboratory detection, a 3D-printed portable device was designed which can eliminate the environmental interference to improve detection accuracy. The developed multifunctional platform also has the advantages of simple operation and low cost, suggesting its great potential for applications in food and agricultural fields.
期刊介绍：
As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.
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