钙（II）催化的亚磺酰亚胺环戊烯酮的合成

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED Advanced Synthesis & Catalysis Pub Date : 2024-10-28 DOI:10.1002/adsc.202401085

Vincent Gandon, Aurélien Alix, Nicolas S. George, Régis Guillot, Emilie Kolodziej, Christophe Bour, Xiangmeng Chen

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引用次数: 0

摘要

通过钙（II）催化的偶氮-Piancatelli 反应，制备了一系列 4-亚磺酰亚胺环戊-2-烯-1-酮，收率为 35% 至 99%，其中包括对映体形式。根据其取代模式，可以对这些支架进行多种非对映选择性化学转化，从而获得环戊烷衍生物。这项研究开辟了环戊烷基支架的合成途径，也为探索药物发现的相关化学空间铺平了道路。

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Calcium(II)-Catalyzed Synthesis of Sulfoximinocyclopentenones

A series of 4-sulfoximinocyclopent-2-en-1-ones were prepared in 35 to 99% yield through a calcium(II)-catalyzed aza-Piancatelli reaction, including in enantioenriched form. Depending on their substitution pattern, diverse diastereoselective chemical transformations can be applied to these scaffolds, allowing access to cyclopentane derivatives. This study opens synthetic routes to cyclopentane-based scaffolds and also paves the way for the exploration of the associated chemical space in drug discovery.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.