电压门控钾通道 α 亚基在心血管系统中的作用

Q3 Medicine 生理学报 Pub Date : 2024-10-25
Jin-Ru Yang, Peng Huang, Shu-Kuan Ling
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引用次数: 0

摘要

电压门控离子通道(VGIC)是细胞兴奋、协调骨骼肌和心肌收缩以及实现神经信号传导的核心。其中,电压门控钾(Kv)通道在心脏电生理学中尤其重要,特别是在心脏动作电位的复极阶段。在心肌细胞中,Kv 通道与包括电传导在内的多种复杂功能密不可分。尽管 Kv 通道非常重要,但有关心血管疾病的研究却非常有限。本综述全面总结了 Kv 通道结构的复杂性,描述了通道门控、表达和膜定位所涉及的调控机制。此外,我们还研究了不同 Kv α 亚基在调节 Kv 通道中的作用及其对心脏重塑的影响,并评估了靶向 Kv 通道开发抗心律失常疗法的潜力。
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Role of voltage-gated potassium channel α subunits in cardiovascular system.

Voltage-gated ion channels (VGICs) are central to cellular excitation, orchestrating skeletal and cardiac muscle contractions and enabling neural signal transduction. Among these, voltage-gated potassium (Kv) channels are particularly significant in cardiac electrophysiology, especially during the repolarization phase of the cardiac action potential. In cardiac myocytes, Kv channels are integral to a multitude of sophisticated functions, including electrical conduction. Despite their importance, research on Kv channels in the context of cardiovascular diseases is limited. This review offers a comprehensive summary of the structural complexities of Kv channels, delineating the regulatory mechanisms involved in channel gating, expression, and membrane localization. Additionally, we examine the role of different Kv α-subunits in modulating Kv channels and their impact on cardiac remodeling, and assess the potential of targeting Kv channels for the development of anti-arrhythmic therapies.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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