新辅助化疗后肥胖对早期乳腺癌患者病理完全缓解的影响:德国一所大学乳腺中心的回顾性研究。

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Archives of Gynecology and Obstetrics Pub Date : 2024-10-28 DOI:10.1007/s00404-024-07786-7
Johannes Felix Englisch, Alexander Englisch, Dominik Dannehl, Kenneth Eissler, Christian Martin Tegeler, Sabine Matovina, Léa Louise Volmer, Diethelm Wallwiener, Sara Y Brucker, Andreas Hartkopf, Tobias Engler
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引用次数: 0

摘要

目的:乳腺癌是全球妇女因癌症死亡的主要原因。新辅助化疗(NACT)是治疗局部晚期非转移性乳腺癌的基础疗法。病理完全反应(pCR)通常被用作长期疗效的替代指标。本研究探讨了肥胖(定义为体重指数(BMI)超过 30 kg/m2)对接受 NACT 治疗的早期乳腺癌(eBC)患者获得病理完全反应的影响:图宾根大学对接受 NACT 治疗的 eBC 患者进行了回顾性分析。主要目的是评估肥胖对获得 pCR 的影响。在调整年龄、肿瘤分期、分级和化疗强度等协变量后,采用逻辑回归分析确定治疗前体重指数与pCR之间的关系:研究共纳入了 325 名患者,其中 24% 属于肥胖。虽然单变量逻辑回归分析显示肥胖对获得 pCR 的几率没有显著影响,但考虑到协变量的多变量分析表明,肥胖患者获得 pCR 的可能性明显更高:结论:在这项回顾性研究中,肥胖对接受 NACT 治疗的 eBC 癌症患者获得 pCR 的可能性有显著影响。虽然肥胖是乳腺癌发生和发展的一个已知风险因素,但在我们的研究中,肥胖对 NACT 在获得 pCR 方面的疗效产生了积极影响。这些研究结果为文献中正在进行的争论做出了贡献,但应考虑到回顾性设计和潜在的不可控因素。
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Impact of obesity on pathological complete remission in early stage breast cancer patients after neoadjuvant chemotherapy: a retrospective study from a German University breast center.

Purpose: Breast cancer is a primary cause of cancer-related death among women worldwide. Neoadjuvant chemotherapy (NACT) is a cornerstone treatment for locally advanced, non-metastatic breast cancer. Achieving pathological complete response (pCR) is often used as a surrogate marker for long-term outcomes. This study examines the impact of obesity, defined by a body mass index (BMI) over 30 kg/m2, on achieving pCR in patients with early stage breast cancer (eBC) undergoing NACT.

Methods: A retrospective analysis was conducted on patients with eBC treated with NACT at the University of Tübingen. The primary objective was to assess the impact of obesity on achieving pCR. Logistic regression analysis was used to determine the association between pre-treatment BMI and pCR, adjusting for covariates such as age, tumor stage, grading, and chemotherapy intensity.

Results: The study included 325 patients, with 24% classified as obese. While the univariate logistic regression analysis showed no significant impact of obesity on the odds ratio of achieving pCR, the multivariate analysis, accounting for covariates, demonstrated that obese patients had a significantly higher likelihood of achieving pCR.

Conclusion: In this retrospective study, obesity significantly affected the likelihood of achieving pCR in patients with eBC cancer undergoing NACT after adjusting for covariates. While obesity is a known risk factor for breast cancer development and progression, its impact on the efficacy of NACT in terms of achieving pCR was positive in our study. These findings contribute to the ongoing debate in the literature, though the retrospective design and potential uncontrolled factors should be considered.

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来源期刊
CiteScore
4.70
自引率
15.40%
发文量
493
审稿时长
1 months
期刊介绍: Founded in 1870 as "Archiv für Gynaekologie", Archives of Gynecology and Obstetrics has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe. "The Archives of Gynecology and Obstetrics" is circulated in over 40 countries world wide and is indexed in "PubMed/Medline" and "Science Citation Index Expanded/Journal Citation Report". The journal publishes invited and submitted reviews; peer-reviewed original articles about clinical topics and basic research as well as news and views and guidelines and position statements from all sub-specialties in gynecology and obstetrics.
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