使用新型多卤代乙烯基醚通过交叉偶联反应合成氟烯和氟炔。

IF 2.2 4区 化学 Q2 CHEMISTRY, ORGANIC Beilstein Journal of Organic Chemistry Pub Date : 2024-10-24 eCollection Date: 2024-01-01 DOI:10.3762/bjoc.20.226
Yukiko Karuo, Keita Hirata, Atsushi Tarui, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote
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引用次数: 0

摘要

在本研究中,我们利用新型多卤代氟乙烯基醚,开发了通过铃木-宫浦(Suzuki-Miyaura)和园柄(Sonogashira)交叉偶联反应合成氟烯和氟炔的方法,这种多卤代氟乙烯基醚很容易从苯酚和 2-溴-2-氯-1,1,1-三氟乙烷(卤代甲烷)的反应中制备出来。这些反应利用多卤代氟乙烯基醚含有一个活性溴原子的独特结构,以中等至高产率制备出一系列氟烯和氟炔。
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Synthesis of fluoroalkenes and fluoroenynes via cross-coupling reactions using novel multihalogenated vinyl ethers.

In this study, we develop the synthesis methods of fluoroalkenes and fluoroenynes via Suzuki-Miyaura and Sonogashira cross-coupling reactions using novel multihalogenated fluorovinyl ethers, which are easily prepared from the reaction between phenols and 2-bromo-2-chloro-1,1,1-trifluoroethane (halothane). These reactions make use of the unique structure of multihalogenated fluorovinyl ethers, which contains a reactive bromine atom, to afford a series of fluoroalkenes and fluoroenynes in moderate to high yields.

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来源期刊
CiteScore
4.90
自引率
3.70%
发文量
167
审稿时长
1.4 months
期刊介绍: The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.
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