评估恶性肿瘤患者的常见皮肤病以及癌症治疗的皮肤副作用。

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY Cutaneous and Ocular Toxicology Pub Date : 2024-10-29 DOI:10.1080/15569527.2024.2421570
Funda Tamer, Sheyda Gharehdaghi, Esra Adisen
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引用次数: 0

摘要

目的:恶性肿瘤患者皮肤疾病的多样性导致诊断困难,并使癌症治疗复杂化。此外,化疗药物和新型治疗方案的使用越来越多,增加了出现各种皮肤副作用的风险,在癌症治疗过程中需要皮肤科医生。我们对恶性肿瘤患者的皮肤病和癌症治疗的皮肤副作用进行了调查:回顾性审查了 2018 年 7 月至 2023 年 4 月期间在皮肤科门诊接受评估的癌症患者的病历:本研究共纳入872名癌症患者,其中女性374名,男性498名。急性髓性白血病是最常见的恶性肿瘤,其次是多发性骨髓瘤和浸润性乳腺导管癌。89名(10.2%)患者在干细胞移植后出现移植物抗宿主疾病,16名(1.8%)患者出现放射性皮炎。大疱性药物疹和手足综合征是化疗药物最常见的皮肤副作用。卡培他滨是手足综合征最常见的病原体。蜂窝织炎是癌症患者最常见的细菌感染,而带状疱疹则是最常见的病毒感染。在引起痤疮样药物疹的化疗药物中,西妥昔单抗和阿糖胞苷最为常见。27.3%的患者面部红斑与使用阿糖胞苷有关:结论:确定癌症患者常见的皮肤病以及化疗药物引起的皮肤副作用有助于采取预防措施、开发特异性的有效治疗方法、确定最合适的癌症治疗方案以及提高患者对癌症治疗的依从性。
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Evaluation of the common skin diseases in patients with malignancies and the cutaneous side effects of cancer treatments.

Purpose: The diversity of skin diseases in patients with malignancies leads to diagnostic difficulties and complicate cancer treatment. Furthermore, the increasing use of chemotherapy drugs and novel treatment regimens raises the risk of the development of various cutaneous side effects and the need for dermatologists during cancer management. We investigated the skin diseases in patients with malignancies and the cutaneous side effects of cancer treatments.

Methods: Medical records of cancer patients evaluated in the Dermatology clinic between July 2018 and April 2023 were retrospectively reviewed.

Results: This study included 872 cancer patients, 374 females and 498 males. Acute myeloid leukaemia was the most common malignancy, followed by multiple myeloma and invasive ductal breast carcinoma. Graft versus host disease was observed in 89 (10.2%) patients after stem cell transplantation and radiodermatitis developed in 16 (1.8%) patients. Maculopapular drug eruption and hand foot syndrome were the most common cutaneous side effects of chemotherapy drugs. Capecitabine was the most common etiologic agent in hand foot syndrome. Cellulitis was the most frequent bacterial infection in cancer patients, whereas herpes zoster was the most frequent viral infection. Among the chemotherapy drugs that caused acneiform drug eruption, cetuximab and cytarabine were notable. Facial erythema was associated with cytarabine use in 27.3% of patients.

Conclusion: Identifying the common skin diseases in cancer patients and cutaneous side effects due to chemotherapy drugs may help to take preventive measures, develop specific and effective treatments, determine the most appropriate cancer treatment options, and increase patients' compliance with cancer treatment.

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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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