银屑病关节炎的发病机制:从骨髓角度的新认识。

IF 5.2 2区 医学 Q1 RHEUMATOLOGY Current opinion in rheumatology Pub Date : 2024-10-30 DOI:10.1097/BOR.0000000000001064
Fatima Saeed, Iannis E Adamopoulos
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引用次数: 0

摘要

审查目的:银屑病关节炎是一种免疫介导的疾病,主要影响皮肤和关节。它属于风湿性疾病的范畴,风湿性疾病描述了一组密切相关但又截然不同的疾病,其中有许多共同的潜在分子通路。尽管每种疾病的临床表现各不相同,但共同的治疗策略证明了细胞和分子基础的共性。在此,我们简要而全面地概述了白细胞介素(IL)-23/IL-17 轴及其参与导致银屑病关节炎和其他风湿性疾病特有的皮肤和关节双重临床表现的发病机制途径:活化的先天性免疫细胞与适应性免疫之间的相互联系改变了目前的思路,将骨髓等其他器官也列为潜在的疾病起源组织。大量的动物模型和遗传学研究一致认为,IL-23/IL-17 轴具有关键作用,并强调了骨髓细胞活化作为自身炎症和自身免疫性疾病与慢性炎症之间共同途径的重要性。这些发现强调了炎症性关节炎所涉及的错综复杂的免疫机制,并突出了疾病发病机制中的分子机制。
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Pathogenesis of psoriatic arthritis: new insights from a bone marrow perspective.

Purpose of review: Psoriatic arthritis is an immune-mediated disease that primarily affects the skin and joints. It falls under the umbrella term of rheumatic diseases, which describes a group of closely related yet distinct disorders with many common underlying molecular pathways. Despite the distinct clinical manifestation of each disorder, the shared therapeutic strategies attest to the commonality of cellular and molecular underpinnings. Herein we provide a concise yet comprehensive overview of the interleukin (IL)-23/IL-17 axis and its involvement in mechanistic pathways leading to the pathogenesis of this dual skin and joint clinical manifestation which is characteristic of psoriatic arthritis and other rheumatic diseases.

Recent findings: The interconnection between activated innate immune cells and adaptive immunity has transformed current thinking to include other organs such as the bone marrow as potential tissue of disease origin. A plethora of animal models and genetic studies converge on the critical role of IL-23/IL-17 axis, and highlight the importance of myeloid cell activation as common pathways between autoinflammatory and autoimmune diseases and chronic inflammation. These findings underscore the intricate immune mechanisms involved in inflammatory arthritis and highlight molecular mechanisms in disease pathogenesis.

Summary: These insights pave the way for the development of novel diagnostic and therapeutic strategies, with a focus on translating these findings into improved clinical practice.

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来源期刊
Current opinion in rheumatology
Current opinion in rheumatology 医学-风湿病学
CiteScore
9.70
自引率
2.00%
发文量
89
审稿时长
6-12 weeks
期刊介绍: A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
期刊最新文献
Neurovascular dysregulation in systemic sclerosis: novel insights into pathophysiology, diagnosis, and treatment utilizing invasive cardiopulmonary exercise testing. Omics studies in Behçet's disease. Recent advances in immunometabolism in rheumatic diseases. Pathogenesis of psoriatic arthritis: new insights from a bone marrow perspective. VEXAS syndrome: an adult-onset autoinflammatory disorder with underlying somatic mutation.
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