中度至剧烈运动水平和治疗/药物数量在调解体重指数对糖尿病肾病影响中的作用:孟德尔随机研究。

IF 3 3区 医学 Q1 UROLOGY & NEPHROLOGY Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI:10.1080/0886022X.2024.2417738
Shasha Hu, Yuling Chen, Mingjie He, Jun Wen, Aimin Zhong, Dandan Zhan, Zhibin Ye
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引用次数: 0

摘要

背景:体重指数(BMI)与糖尿病肾病(DN)有关。然而,BMI-DN效应的中介因素仍不清楚:方法:进行单变量和多变量孟德尔随机化(MR)分析,以估计六种生活方式(中度至剧烈运动水平、受教育年限、体重指数、白天午睡、接受治疗/药物的次数和咖啡摄入量)与 DN 之间的关系。MR Egger、加权中位数、简单模式和加权模式是逆方差加权的补充方法。敏感性分析包括异质性检验、水平多向性检验和 "一出一进 "检验。此外,还进行了中介 MR 分析,以评估生活方式在 BMI 和 DN 之间的中介作用。结果:进行了单变量和多变量孟德尔随机化(MR)分析,以估计六种生活方式(中强度体力活动水平、受教育年限、体重指数、白天午睡、接受治疗/药物的次数和咖啡摄入量)与 DN 之间的关系。MR Egger、加权中位数、简单模式和加权模式是逆方差加权的补充方法。敏感性分析包括异质性检验、水平多向性检验和一出一进检验。此外,还进行了中介 MR 分析,以评估生活方式在 BMI 和 DN 之间的中介作用。结论:我们的研究结果支持剧烈运动水平和治疗/药物次数在 BMI-DN 影响中的中介作用。
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The role of moderate to vigorous physical activity level and number of treatments/medications in mediating the effect of body mass index on diabetic nephropathy: a Mendelian randomization study.

Background: Body mass index (BMI) is associated with diabetic nephropathy (DN). However, the mediator factors in the BMI-DN effects remain unclear.

Methods: Univariate and multivariate Mendelian randomization (MR) analysis were performed to estimate the association between six lifestyles (moderate to vigorous physical activity levels, years of schooling, BMI, nap during day, number of treatments/medications taken and coffee intake) and DN. MR Egger, Weighted median, Simple mode, and Weighted mode was supplemental methods to Inverse variance weighted. Sensitivity analysis included heterogeneity test, horizontal pleiotropy test, and Leave-One-Out. Additionally, mediation MR was conducted to evaluate the mediating role of lifestyles between BMI and DN. Finally, functional enrichment analysis based on the mediation MR results was performed.

Results: univariate and multivariate Mendelian randomization (MR) analysis were performed to estimate the association between six lifestyles (moderate to vigorous physical activity levels, years of schooling, BMI, nap during day, number of treatments/medications taken and coffee intake) and DN. MR Egger, Weighted median, Simple mode, and Weighted mode was supplemental methods to Inverse variance weighted. Sensitivity analysis included heterogeneity test, horizontal pleiotropy test, and Leave-One-Out. Additionally, mediation MR was conducted to evaluate the mediating role of lifestyles between BMI and DN. Finally, functional enrichment analysis based on the mediation MR results was performed.

Conclusion: our results supported mediation role of vigorous physical activity level and number of treatments/medications in BMI-DN effects.

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来源期刊
Renal Failure
Renal Failure 医学-泌尿学与肾脏学
CiteScore
3.90
自引率
13.30%
发文量
374
审稿时长
1 months
期刊介绍: Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.
期刊最新文献
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