周围神经再生啮齿动物模型的影响因素和修复进展。

IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Regenerative medicine Pub Date : 2024-10-29 DOI:10.1080/17460751.2024.2405318
Timothy C Olsen, Jonnby S LaGuardia, David R Chen, Ryan S Lebens, Kelly X Huang, David Milek, Mark Noble, Jonathan I Leckenby
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引用次数: 0

摘要

周围神经损伤会导致严重的功能障碍,而啮齿动物模型对研究再生至关重要。本综述探讨了影响结果的关键因素。与年龄有关的衰退,如神经纤维密度降低和轴突运输囊泡受损,都会阻碍恢复。激素差异会影响再生,BDNF/trkB 对睾酮和神经生长因子对雌激素信号通路至关重要。物种和品系选择会影响结果,C57BL/6 小鼠和 Sprague-Dawley 大鼠表现出不同的再生能力。损伤模型--用于早期再生的挤压模型、用于神经病理性疼痛的慢性收缩模型、用于创伤性伸长的拉伸模型以及用于严重撕裂伤的横断模型--提供了对临床相关情况的深入了解。神经移植和导管等修复技术表明,自体移植是间隙超过 3 厘米的黄金标准,成功与否受移植类型和直径的影响。时间进程分析显示,第一个月内的早期退化和再生阶段至关重要,功能恢复在三到六个月内趋于稳定。早期干预通过减少瘢痕组织的形成来优化再生,而后期干预则侧重于再髓鞘化。了解这些因素对于设计强有力的临床前研究以及将研究成果转化为有效的周围神经损伤临床治疗方法至关重要。
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Influencing factors and repair advancements in rodent models of peripheral nerve regeneration.

Peripheral nerve injuries lead to severe functional impairments, with rodent models essential for studying regeneration. This review examines key factors affecting outcomes. Age-related declines, like reduced nerve fiber density and impaired axonal transport of vesicles, hinder recovery. Hormonal differences influence regeneration, with BDNF/trkB critical for testosterone and nerve growth factor for estrogen signaling pathways. Species and strain selection impact outcomes, with C57BL/6 mice and Sprague-Dawley rats exhibiting varying regenerative capacities. Injury models - crush for early regeneration, chronic constriction for neuropathic pain, stretch for traumatic elongation and transection for severe lacerations - provide insights into clinically relevant scenarios. Repair techniques, such as nerve grafts and conduits, show that autografts are the gold standard for gaps over 3 cm, with success influenced by graft type and diameter. Time course analysis highlights crucial early degeneration and regeneration phases within the first month, with functional recovery stabilizing by three to six months. Early intervention optimizes regeneration by reducing scar tissue formation, while later interventions focus on remyelination. Understanding these factors is vital for designing robust preclinical studies and translating research into effective clinical treatments for peripheral nerve injuries.

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来源期刊
Regenerative medicine
Regenerative medicine 医学-工程:生物医学
CiteScore
4.20
自引率
3.70%
发文量
82
审稿时长
6-12 weeks
期刊介绍: Regenerative medicine replaces or regenerates human cells, tissue or organs, to restore or establish normal function*. Since 2006, Regenerative Medicine has been at the forefront of publishing the very best papers and reviews covering the entire regenerative medicine sector. The journal focusses on the entire spectrum of approaches to regenerative medicine, including small molecule drugs, biologics, biomaterials and tissue engineering, and cell and gene therapies – it’s all about regeneration and not a specific platform technology. The journal’s scope encompasses all aspects of the sector ranging from discovery research, through to clinical development, through to commercialization. Regenerative Medicine uniquely supports this important area of biomedical science and healthcare by providing a peer-reviewed journal totally committed to publishing the very best regenerative medicine research, clinical translation and commercialization. Regenerative Medicine provides a specialist forum to address the important challenges and advances in regenerative medicine, delivering this essential information in concise, clear and attractive article formats – vital to a rapidly growing, multidisciplinary and increasingly time-constrained community. Despite substantial developments in our knowledge and understanding of regeneration, the field is still in its infancy. However, progress is accelerating. The next few decades will see the discovery and development of transformative therapies for patients, and in some cases, even cures. Regenerative Medicine will continue to provide a critical overview of these advances as they progress, undergo clinical trials, and eventually become mainstream medicine.
期刊最新文献
Industry updates from the field of stem cell research and regenerative medicine in August 2024. Ultrasound-guided injection using leucocyte-rich platelet-rich plasma for treatment of meniscal injuries in a duathlete: a case report. Influencing factors and repair advancements in rodent models of peripheral nerve regeneration. Extracellular vesicles for corneal regeneration: the new frontier. Industry updates from the field of stem cell research and regenerative medicine in July 2024.
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