在为期 104 周的致癌性研究中,Sprague Dawley 大鼠自发性非肿瘤性病变的历史控制背景发生率。

IF 1.4 4区 医学 Q3 PATHOLOGY Toxicologic Pathology Pub Date : 2024-10-29 DOI:10.1177/01926233241289116
Marie Bockenstedt, Amit Kumar, Victoria Laast, Alok Sharma
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引用次数: 0

摘要

在威斯康星州麦迪逊市的北美实验室早期开发公司(North American Labcorp Early Development, Inc)进行的为期 104 周的致癌性研究中,从约 1800 只雌雄 Sprague Dawley (SD) 对照组大鼠身上收集了显微镜观察数据,并对这些数据进行了回顾性评估,以确定是否存在自发性非肿瘤性结果。本研究提供了在 104 周致癌性研究期间 SD 大鼠各器官系统中最常见的自发性非肿瘤性显微镜检查结果的发生率。一些最常见的自发性背景发现包括心肌病、慢性进行性肾病、子宫囊性内膜增生、前列腺炎症、肺泡巨噬细胞浸润、肝细胞空泡化、胆管增生和肝脏嗜碱性病灶;胰腺纤维化;脾髓外造血和色素沉着;淋巴细胞减少和胸腺上皮增生;大脑腹侧受压;肾上腺皮质囊性变性和增生;乳腺增生。雄性 SD 大鼠最常见的非肿瘤性病变是慢性进行性肾病(80.9%)和啮齿动物进行性心肌病(73.2%)。雌性SD大鼠最常见的非肿瘤性病变是肾上腺皮质囊性变性(64.7%)和垂体肿瘤导致的大脑腹侧压迫(62.7%)。
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Historical Control Background Incidence of Spontaneous Nonneoplastic Lesions of Sprague Dawley Rats in 104-Week Carcinogenicity Studies.

Microscopic observation data collected from approximately 1800 male and female Sprague Dawley (SD) control rats used on 104-week carcinogenicity studies performed at North American Labcorp Early Development, Inc, Madison, WI, were retrospectively evaluated for spontaneous nonneoplastic findings. This study provides incidence of the most common spontaneous nonneoplastic microscopic findings in each organ system of SD rats encountered during 104-week carcinogenicity studies. Some of the most common spontaneous background findings were cardiomyopathy; chronic progressive nephropathy; uterine cystic endometrial hyperplasia; prostate inflammation; pulmonary alveolar macrophage infiltrates; hepatocyte vacuolation, bile duct hyperplasia, and basophilic foci in the liver; pancreatic fibrosis; splenic extramedullary hematopoiesis and pigment; decreased lymphocytes and epithelial hyperplasia in the thymus; ventral brain compression; cystic degeneration and hyperplasia of the adrenal cortex; and mammary gland hyperplasia. The most common nonneoplastic findings in male SD rats were chronic progressive nephropathy (80.9%) and rodent progressive cardiomyopathy (73.2%). The most common nonnenoplastic findings in female SD rats were cystic degeneration of the adrenal cortex (64.7%) and ventral compression of the brain due to pituitary neoplasms (62.7%).

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来源期刊
Toxicologic Pathology
Toxicologic Pathology 医学-病理学
CiteScore
4.70
自引率
20.00%
发文量
57
审稿时长
6-12 weeks
期刊介绍: Toxicologic Pathology is dedicated to the promotion of human, animal, and environmental health through the dissemination of knowledge, techniques, and guidelines to enhance the understanding and practice of toxicologic pathology. Toxicologic Pathology, the official journal of the Society of Toxicologic Pathology, will publish Original Research Articles, Symposium Articles, Review Articles, Meeting Reports, New Techniques, and Position Papers that are relevant to toxicologic pathology.
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