[脑脊液和血清中 SIL-2R、eNOS 和 CD93 水平与儿童病毒性脑炎病情发展和预后的关系]。

Q3 Medicine 中国当代儿科杂志 Pub Date : 2024-10-15 DOI:10.7499/j.issn.1008-8830.2405043

Jie Song, Yi-Lin Wang, Jia-Qi Chu

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引用次数: 0

摘要

研究目的研究脑脊液和血清中可溶性白细胞介素-2受体（SIL-2R）、内皮一氧化氮合酶（eNOS）和分化簇93（CD93）水平与儿童病毒性脑炎（VE）病情进展和预后的关系：方法：前瞻性地选取2021年1月至2024年1月期间收治的102名VE患儿作为VE组。根据疾病进展情况将患者分为轻度亚组（64 例）和重度亚组（38 例）。根据预后情况，患者还被分为预后良好亚组（29 例）和预后不良亚组（73 例）。对照组为 102 名患有中枢神经系统疾病的儿童，他们在同一时期接受了检查，但未发现 VE。评估了导致 VE 患儿预后不良的因素，以及脑脊液和血清中的 SIL-2R、eNOS 和 CD93 对 VE 患儿预后不良的预测价值：结果：脑脊液和血清中的SIL-2R、eNOS和CD93水平在VE组、重症亚组和预后不良亚组（PPPPConclusions：VE患儿脑脊液和血清中的SIL-2R、eNOS和CD93水平明显升高，它们与VE的进展和预后有关。

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[Relationship of cerebrospinal fluid and serum levels of SIL-2R, eNOS, and CD93 with the progression and prognosis of viral encephalitis in children].

Objectives: To investigate the relationship of cerebrospinal fluid and serum levels of soluble interleukin-2 receptor (SIL-2R), endothelial nitric oxide synthase (eNOS), and cluster of differentiation 93 (CD93) with the progression and prognosis of viral encephalitis (VE) in children.

Methods: Prospectively, 102 children with VE admitted from January 2021 to January 2024 were selected as the VE group. The patients were divided into a mild subgroup (64 patients) and a severe subgroup (38 patients) according to disease progression. The patients were also divided into a good prognosis subgroup (29 patients) and a poor prognosis subgroup (73 patients) according to prognosis. A control group of 102 children with central nervous system diseases who were examined and found not to have VE during the same period was selected. The factors contributing to the poor prognosis of children with VE and the predictive value of SIL-2R, eNOS, and CD93 in cerebrospinal fluid and serum for the poor prognosis of children with VE were evaluated.

Results: Cerebrospinal fluid and serum SIL-2R, eNOS, and CD93 levels were significantly increased in the VE group, severe subgroup, and poor prognosis subgroup (P<0.05). Multivariate logistic regression analysis showed that high SIL-2R, eNOS, and CD93 levels in cerebrospinal fluid and serum were risk factors for poor prognosis in children with VE (P<0.05). Receiver operating characteristic curve analysis showed that the combination of cerebrospinal fluid SIL-2R, eNOS, and CD93 was superior to these individual indicators in prediction of poor prognosis in children with VE (P<0.05). Similarly, the combination of serum SIL-2R, eNOS, and CD93 was superior to these individual indicators in prediction of poor prognosis in children with VE (P<0.05).

Conclusions: The cerebrospinal fluid and serum levels of SIL-2R, eNOS, and CD93 are significantly elevated in children with VE, and they are associated with VE progression and prognosis.

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.