母体低蛋白饮食会导致新生大鼠突触素表达和乳汁脂肪酸谱的性别差异。

IF 2.4 Q3 NUTRITION & DIETETICS Journal of Nutritional Science Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI:10.1017/jns.2024.46
Paola C Bello-Medina, Mauricio Díaz-Muñoz, Sandra Teresita Martín Del Campo, Fermín Paul Pacheco-Moisés, Claudia Flores Miguel, Raquel Cobián Cervantes, Perla Belén García Solano, Mónica Navarro-Meza
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引用次数: 0

摘要

健康和疾病的发育起源假说强调了早期生活环境与后代长期健康结果之间的联系。例如,母体在孕期和哺乳期限制蛋白质摄入会导致后代在出生后出现不良的代谢和认知结果。因此,在本研究中,我们评估了等热量低蛋白饮食(ILPD)是否会影响母乳中的脂肪酸谱、海马突触素(Syn)比率以及男女后代新生儿期的氧化应激标记物。本研究旨在评估 ILPD 对母乳中脂肪酸含量、海马突触素(Syn)比率以及雌雄大鼠新生儿期氧化应激指标的影响。雌性 Wistar 大鼠在妊娠期至哺乳期第 10 天期间食用对照组饮食或 ILPD。评估血清和肝脏中的氧化应激标记物。所有定量均在出生后第 10 天进行。结果显示ILPD导致母乳量和多不饱和脂肪酸含量分别下降了38.5%和17.4%。雄性后代海马Syn比率显著下降(海马CA1锥体和CA1 oriens下降98%,CA3锥体层下降83%,CA3透明层下降80%,CA3 oriens层下降81%)。雄性后代的血清和肝脏中的原氧化状态有所增加。因此,这些数据表明,在妊娠期和哺乳期,雄性后代比雌性后代更容易受到ILPD的影响。
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A maternal low-protein diet results in sex-specific differences in synaptophysin expression and milk fatty acid profiles in neonatal rats.

The developmental origins of health and disease hypothesis have highlighted the link between early life environment and long-term health outcomes in offspring. For example, maternal protein restriction during pregnancy and lactation can result in adverse metabolic and cognitive outcomes in offspring postnatal. Hence, in the present study, we assess whether an isocaloric low-protein diet (ILPD) affects the fatty acid profile in breast milk, the hippocampal synaptophysin (Syn) ratio, and the oxidative stress markers in the neonatal stage of male and female offspring. The aim of this work was to assess the effect of an ILPD on the fatty acid profile in breast milk, quantified the hippocampal synaptophysin (Syn) ratio and oxidative stress markers in neonatal stage of male and female offspring. Female Wistar rats were fed with either a control diet or an ILPD during gestation to day 10 of lactation. Oxidative stress markers were assessed in serum and liver. All quantifications were done at postnatal day 10. The results showed: ILPD led to decreases of 38.5% and 17.4% in breast milk volume and polyunsaturated fatty acids content. Significant decreases of hippocampal Syn ratio in male offspring (decreases of 98% in hippocampal CA1 pyramidal and CA1 oriens, 83%, stratum pyramidal in CA3, 80%, stratum lucidum in CA3, and 81% stratum oriens in CA3). Male offspring showed an increase in pro-oxidant status in serum and liver. Thus, the data suggest that male offspring are more vulnerable than females to an ILPD during gestation and lactation.

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来源期刊
Journal of Nutritional Science
Journal of Nutritional Science NUTRITION & DIETETICS-
CiteScore
3.00
自引率
0.00%
发文量
91
审稿时长
7 weeks
期刊介绍: Journal of Nutritional Science is an international, peer-reviewed, online only, open access journal that welcomes high-quality research articles in all aspects of nutrition. The underlying aim of all work should be, as far as possible, to develop nutritional concepts. JNS encompasses the full spectrum of nutritional science including public health nutrition, epidemiology, dietary surveys, nutritional requirements, metabolic studies, body composition, energetics, appetite, obesity, ageing, endocrinology, immunology, neuroscience, microbiology, genetics, molecular and cellular biology and nutrigenomics. JNS welcomes Primary Research Papers, Brief Reports, Review Articles, Systematic Reviews, Workshop Reports, Letters to the Editor and Obituaries.
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