通过微膜反应器在室温下连续生产超顺磁性 Fe3O4 纳米粒子的精确空气氧化技术

IF 3.9 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY RSC Advances Pub Date : 2024-10-29 DOI:10.1039/D4RA05373G
Jie Fang, Hongyun Li, Wangyu Zhu and Baogeng Xie
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引用次数: 0

摘要

超顺磁性氧化铁纳米粒子(SPIONs)在生物医学领域有着广泛的应用,如药物输送、磁共振成像(MRI)造影剂、细胞分离、组织修复等。纯净均匀的 SPIONs 的合成过程繁琐,需要复杂的前体、有机溶剂、封端剂和/或高温的辅助。在此,我们报告了一种在室温下不使用任何表面活性剂在水性微薄膜中连续大规模生产纯净均匀的 SPIONs 的方法。在连续流动的微薄膜中,通过过程强化精确控制了空气氧化速率和纳米晶体形成动力学。铁(II)的精确氧化是圆盘旋转速度和进料浓度的协同作用。生产过程在室温水介质中连续进行,产量高达 55.4 克/小时。通过 XRD 和比色法证明所获得的产品纯度很高。生成的 SPIONs 尺寸分布较窄,从 6.5 纳米到 12.6 纳米不等。所有尺寸的纳米粒子都显示出特有的超顺磁性,其中 12.6 nm 的 SPION 表现出最高的磁化饱和度 (Ms),达到 87 emu g-1。
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Precise air oxidation for continuous production of superparamagnetic Fe3O4 nanoparticles at room temperature through a microfilm reactor

Superparamagnetic iron oxide nanoparticles (SPIONs) find vast applications in biomedicine such as drug delivery, magnetic resonance imaging (MRI) contrast agents, cell separation, tissue repair, etc. The synthesis of pure and uniform SPIONs involves tedious processes, complex precursors, the assistance of organic solvents, capping agents and/or high temperature. Herein, we report a continuous mass production of pure and uniform SPIONs in aqueous microfilm at room temperature without using any surfactant. The air oxidation rate and nanocrystal formation kinetics were precisely controlled by process intensification in the continuously flowing microfilm. Precise oxidation of Fe(II) is a synergy of disc spinning speed and feeding concentration. The production process was continuous and conducted at room temperature in an aqueous medium with a high yield of 55.4 g h−1. The obtained products were proved to be highly pure through XRD and a colorimetric method. The resulting SPIONs exhibited a narrow size distribution, ranging from 6.5 to 12.6 nm. All sizes of the produced nanoparticles showed characteristic superparamagnetism, with the 12.6 nm SPIONs exhibiting the highest magnetization saturation (Ms) of 87 emu g−1.

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来源期刊
RSC Advances
RSC Advances chemical sciences-
CiteScore
7.50
自引率
2.60%
发文量
3116
审稿时长
1.6 months
期刊介绍: An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
期刊最新文献
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