急性心肌梗死女性患者甘油三酯-葡萄糖指数的重要预测和预后作用：一项回顾性队列研究

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL Health Science Reports Pub Date : 2024-10-27 DOI:10.1002/hsr2.70157

Xiao-xia Qiu, Yong-li Chen, Xin-kang Wang, Re-hua Wang

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引用次数: 0

摘要

背景和目的作为急性心肌梗死（AMI）患者胰岛素抵抗（IR）的生物标志物，甘油三酯-葡萄糖指数（TyG 指数）受到了广泛关注。然而，由于传统上认为急性心肌梗死主要影响男性，因此大多数有关急性心肌梗死的研究都集中在男性患者身上。因此，本研究以女性急性心肌梗死患者为对象，调查 TyG 指数与患者预后之间的潜在相关性。方法本研究共纳入2017年1月至2019年12月期间因AMI入住福建省立医院的320名女性患者。TyG指数的计算公式如下：ln[空腹甘油三酯（TG）（mg/dL）×空腹血浆葡萄糖（FPG）（mg/dL）/2]。研究的主要终点是主要不良心脑血管事件（MACCE）的发生率，包括全因死亡率、心肌梗死、重复血管重建、心衰再住院和中风。采用 Cox 比例危险回归模型研究了女性患者的 TyG 指数与不良预后之间的关系。结果据估计，最终有 111 名患者发生了 MACCE。TyG指数高的女性患糖尿病、心率升高和血红蛋白A1c的比例更高，接受血栓抽吸和支架置入的可能性也更大。研究发现，TyG 指数与高血压、糖尿病、低密度脂蛋白胆固醇、血红蛋白 A1c 和受损血管的患病率呈正相关。不过，这种相关性并不高，但在统计学上有显著意义。此外，在对常规风险因素进行调整后，TyG 指数（HR：4.292，95% CI：2.784-6.616，p <0.001）与 MACCEs 具有独立相关性。结论作为一种独立的风险预测指标，TyG 指数有可能改善女性 AMI 患者的临床预后。

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Vital Predictive and Prognostic Roles of Triglyceride-Glucose Index in Women With Acute Myocardial Infarction: A Retrospective Cohort Study

Background and Aims

As a biomarker of insulin resistance (IR) in patients with acute myocardial infarction (AMI), the triglyceride-glucose index (TyG index) has received significant attention. However, most research on AMI has focused on male patients, as it is traditionally believed to primarily affect males. Therefore, this study was conducted on a female population with AMI to investigate the potential correlation between the TyG index and their outcomes.

Methods

A total of 320 women who were admitted to Fujian Provincial Hospital for AMI between January 2017 and December 2019 were included in this study. The TyG index was calculated using the following formula: ln [fasting triglycerides (TG) (mg/dL) × fasting plasma glucose (FPG) (mg/dL)/2]. The primary endpoint of the study was the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs), which included all-cause mortality, myocardial infarction, repeat revascularization, rehospitalization for heart failure and stroke. The association between the TyG index and unfavorable outcomes in female patients was investigated using the Cox proportional hazards regression model.

Results

It was ultimately estimated that 111 patients developed MACCEs. Females with high TyG indices had a higher prevalence of diabetes, elevated heart rates, and hemoglobin A1c, as well as a higher likelihood of undergoing thrombus aspiration and stent placement. The TyG index was found to be positively correlated with the prevalence of hypertension, diabetes, low-density lipoprotein cholesterol, hemoglobin A1c, and damaged vessels. However, this correlation was modest, yet statistically significant. Furthermore, after adjusting for conventional risk factors, the TyG index (HR: 4.292, 95% CI: 2.784–6.616, p < 0.001) was independently associated with MACCEs.