{"title":"副花叶杜仲水醇提取物对 2 型糖尿病患者炎症和氧化应激参数的基因表达和血清水平的影响：随机对照临床试验","authors":"Arash Karimi , Elham Dalir Abdollahinia , Saeed Ostadrahimi , Mahdi Vajdi , Majid Mobasseri , Amir Bahrami , Helda Tutunchi , Farzad Najafipour","doi":"10.1016/j.jff.2024.106528","DOIUrl":null,"url":null,"abstract":"<div><div>The present study examined the effects of hydroalcoholic extract of <em>Fumaria parviflora</em> (FP) on gene expression and serum levels of inflammatory and oxidative stress parameters in patients with type 2 diabetes. A total of 70 overweight or obese patients with diabetes were randomly assigned to either a FP (500 mg/day) or a placebo (cornstarch 500 mg/day) group for eight weeks. At the endpoint, mRNA expression levels of the B cell lymphoma-2 (BCL-2) and nuclear factor erythroid 2–related factor 2 (Nrf-2) were significantly higher in the FP group compared to placebo. In comparison, expression levels of the Bcl-2-associated protein x (BAX), nuclear factor kappa B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were significantly lower in the FP group. FP supplementation resulted in a significant reduction in serum levels of intercellular adhesion molecule-1 (ICAM), interleukin-6, tumor necrosis factor-alpha, and malondialdehyde, as well as an increase in serum levels of antioxidant parameters.</div><div><strong>Trial registration:</strong> Iranian Registry of Clinical Trials (IRCT), IRCT20130610013612N11, <span><span>https://irct.behdasht.gov.ir/trial/58544</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106528"},"PeriodicalIF":3.8000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of hydroalcoholic extract of Fumaria parviflora Lam on gene expression and serum levels of inflammatory and oxidative stress parameters in patients with type 2 diabetes: A randomized controlled clinical trial\",\"authors\":\"Arash Karimi , Elham Dalir Abdollahinia , Saeed Ostadrahimi , Mahdi Vajdi , Majid Mobasseri , Amir Bahrami , Helda Tutunchi , Farzad Najafipour\",\"doi\":\"10.1016/j.jff.2024.106528\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The present study examined the effects of hydroalcoholic extract of <em>Fumaria parviflora</em> (FP) on gene expression and serum levels of inflammatory and oxidative stress parameters in patients with type 2 diabetes. A total of 70 overweight or obese patients with diabetes were randomly assigned to either a FP (500 mg/day) or a placebo (cornstarch 500 mg/day) group for eight weeks. At the endpoint, mRNA expression levels of the B cell lymphoma-2 (BCL-2) and nuclear factor erythroid 2–related factor 2 (Nrf-2) were significantly higher in the FP group compared to placebo. In comparison, expression levels of the Bcl-2-associated protein x (BAX), nuclear factor kappa B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were significantly lower in the FP group. FP supplementation resulted in a significant reduction in serum levels of intercellular adhesion molecule-1 (ICAM), interleukin-6, tumor necrosis factor-alpha, and malondialdehyde, as well as an increase in serum levels of antioxidant parameters.</div><div><strong>Trial registration:</strong> Iranian Registry of Clinical Trials (IRCT), IRCT20130610013612N11, <span><span>https://irct.behdasht.gov.ir/trial/58544</span><svg><path></path></svg></span>.</div></div>\",\"PeriodicalId\":360,\"journal\":{\"name\":\"Journal of Functional Foods\",\"volume\":\"122 \",\"pages\":\"Article 106528\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-10-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Functional Foods\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1756464624005309\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Functional Foods","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756464624005309","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Effects of hydroalcoholic extract of Fumaria parviflora Lam on gene expression and serum levels of inflammatory and oxidative stress parameters in patients with type 2 diabetes: A randomized controlled clinical trial
The present study examined the effects of hydroalcoholic extract of Fumaria parviflora (FP) on gene expression and serum levels of inflammatory and oxidative stress parameters in patients with type 2 diabetes. A total of 70 overweight or obese patients with diabetes were randomly assigned to either a FP (500 mg/day) or a placebo (cornstarch 500 mg/day) group for eight weeks. At the endpoint, mRNA expression levels of the B cell lymphoma-2 (BCL-2) and nuclear factor erythroid 2–related factor 2 (Nrf-2) were significantly higher in the FP group compared to placebo. In comparison, expression levels of the Bcl-2-associated protein x (BAX), nuclear factor kappa B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were significantly lower in the FP group. FP supplementation resulted in a significant reduction in serum levels of intercellular adhesion molecule-1 (ICAM), interleukin-6, tumor necrosis factor-alpha, and malondialdehyde, as well as an increase in serum levels of antioxidant parameters.
Trial registration: Iranian Registry of Clinical Trials (IRCT), IRCT20130610013612N11, https://irct.behdasht.gov.ir/trial/58544.
期刊介绍：
Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies.
The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients.
The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
