纳米酶增强酶控制:组织工程中精确和持续酶活性的计算策略

IF 2 3区 化学 Q4 CHEMISTRY, PHYSICAL Chemical Physics Pub Date : 2024-10-11 DOI:10.1016/j.chemphys.2024.112474
Maryam Fatima , Bandar Almohsen , S. Iqbal , Youming Lei , Alessandro Nutini
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引用次数: 0

摘要

纳米材料通过显著增强酶介导的化学过程和细胞活动,正在彻底改变组织工程学,从而推动更有效治疗策略的开发。这项研究深入探讨了组织基质中酶扩散的复杂动态,提供了一个全面的计算建模框架,旨在优化组织支架中的酶浓度控制。通过先进的数值算法和计算分析,该研究模拟了调节纳米酶水平的最佳控制策略,确保支架内酶活性的精确性和持续性。这项工作的一个新颖之处是整合了视频记录,从而丰富了对纳米材料与生物组织之间复杂相互作用的理解,提供了对系统运行动态的详细见解。这项研究填补了实验方法与理论模型之间的空白,与化学物理和物理化学领域的前沿研究保持一致,为应对组织工程挑战提供了新方法。研究结果强调了纳米材料在实现精确酶控制方面的关键作用,这对于开发先进的仿生系统和改善治疗效果至关重要。这项研究为酶传递机制及其在生物医学中的应用提供了重要的新见解,从而为化学、生物学和材料科学领域正在进行的物理现象前沿研究做出了贡献。这项研究不仅强调了创新方法在组织工程中的重要性,还为未来的实验验证和潜在临床应用奠定了基础。
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Nanozyme-enhanced enzyme control: Computational strategies for precise and sustained enzymatic activity in tissue engineering
Nanomaterials are revolutionizing tissue engineering by significantly enhancing enzyme-mediated chemical processes and cellular activities, thereby advancing the development of more effective therapeutic strategies. This research delves into the intricate dynamics of enzyme diffusion within tissue matrices, providing a comprehensive computational modeling framework aimed at optimizing enzyme concentration control in tissue scaffolds. Through advanced numerical algorithms and computational analysis, the study simulates optimal control strategies for regulating nanozyme levels, ensuring precise and sustained enzymatic activity within the scaffolds. A novel aspect of this work is the integration of videographic records, which offers an enriched understanding of the complex interactions between nanomaterials and biological tissues, providing detailed insights into the system’s operational dynamics. The study bridges the gap between experimental methodologies and theoretical models, aligning with the cutting-edge research in chemical physics and physical chemistry by offering novel approaches to tissue engineering challenges. The findings underscore the critical role of nanomaterials in achieving precise enzymatic control, which is pivotal for the development of advanced biomimetic systems and improved therapeutic outcomes. This work contributes to the ongoing frontier research in physical phenomena within chemistry, biology, and materials science, by providing significant new insights into enzyme delivery mechanisms and their application in biomedical contexts. The research not only highlights the importance of innovative methodologies in tissue engineering but also sets the stage for future experimental validations and potential clinical applications
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来源期刊
Chemical Physics
Chemical Physics 化学-物理:原子、分子和化学物理
CiteScore
4.60
自引率
4.30%
发文量
278
审稿时长
39 days
期刊介绍: Chemical Physics publishes experimental and theoretical papers on all aspects of chemical physics. In this journal, experiments are related to theory, and in turn theoretical papers are related to present or future experiments. Subjects covered include: spectroscopy and molecular structure, interacting systems, relaxation phenomena, biological systems, materials, fundamental problems in molecular reactivity, molecular quantum theory and statistical mechanics. Computational chemistry studies of routine character are not appropriate for this journal.
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