高葡萄糖和缺乏膳食纤维的饮食会导致脂肪在肝脏堆积,但体重不会增加

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry and Biophysics Reports Pub Date : 2024-10-19 DOI:10.1016/j.bbrep.2024.101848
Sonoko Karino , Haruki Usuda , Shoma Kanda , Takayuki Okamoto , Tomomi Niibayashi , Takahisa Yano , Kohji Naora , Koichiro Wada
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引用次数: 0

摘要

本研究调查了高葡萄糖和缺乏膳食纤维的标准热量饮食(称为 HGD [高葡萄糖饮食])是否会诱发小鼠肝脏脂肪堆积。我们在 HGD 开始后的 7 天和 14 天对肝脏脂肪变性进行了评估。HGD组小鼠肝脏甘油三酯和油滴面积在第7天和第14天均有所增加,而体重增加、附睾脂肪重量和血浆甘油三酯水平则不受HGD影响。对肝脏进行的芯片分析表明,摄入 HGD 对脂肪生成相关基因的表达影响最大。此外,摄入 HGD 会诱导肝脏中脂肪酸合成酶、乙酰-CoA 羧化酶 alpha 和硬脂酰-CoA 去饱和酶 1 蛋白的表达,而已知这些蛋白参与了甘油三酯的合成。这些结果表明,摄入 HGD 会导致脂肪在肝脏中蓄积,参与新脂肪生成的酶会增加,但不会伴随体重或肥胖表型。我们的新发现表明,摄入 HGD 可能成为肝脏脂肪变性的温床。
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A diet high in glucose and deficient in dietary fibre causes fat accumulation in the liver without weight gain
This study investigated whether a standard calorie diet that is high in glucose and deficient in dietary fibre (described as HGD [high glucose diet]) induces hepatic fat accumulation in mice. We evaluated hepatic steatosis at 7 days and 14 days after the commencement of the HGD. Hepatic triglycerides and areas of oil droplets increased in the HGD group both at day 7 and day 14, whereas weight gain, weight of epididymal fat, and plasma levels of triglycerides were unaffected by HGD consumption. A microarray analysis of the livers revealed that the expression of lipogenesis-related genes was the most affected by HGD consumption. Furthermore, HGD consumption induced the expression of hepatic proteins of fatty acid synthetase, acetyl-CoA carboxylase alpha, and stearoyl-CoA desaturase 1, which are known to be involved in the synthesis of triglyceride. These results indicate that HGD consumption causes fat accumulation in the liver, with an increase in enzymes that are involved in de novo lipogenesis without an accompanying weight or obesity phenotype. Our new findings suggest that HGD consumption could serve as a breeding ground for liver steatosis.
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来源期刊
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
4.60
自引率
0.00%
发文量
191
审稿时长
59 days
期刊介绍: Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.
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