{"title":"利用射频磁控溅射技术提高氧化铝上 3%掺锰羟基磷灰石涂层的生物活性、硬度和耐摩擦性","authors":"Ranbir Kumar , Deep Shikha , Sanjay Kumar Sinha","doi":"10.1016/j.surfcoat.2024.131481","DOIUrl":null,"url":null,"abstract":"<div><div>Hydroxyapatite (HAP) is a common hard tissue implant material known for its superior biocompatibility and osteoconductivity. However, its poor mechanical strength, brittleness and slow degradation limit the applications. This study explores the enhancement of HAP mechanical properties and bioactivity by coating 3 wt% manganese-doped HAP (Mn-HAP) on another inert biomaterial alumina (Mn-HAP/Al<sub>2</sub>O<sub>3</sub>) substrates using the RF magnetron sputtering technique. Characterization of these samples was performed using Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive X-ray Spectroscopy (EDS), Grazing Incidence X-ray Diffraction (GIXRD), Fourier Transform Infrared Spectroscopy (FTIR) and Brunauer-Emmett-Teller (BET) techniques. Mechanical property was assessed through Vicker's hardness and adhesion of the film was studied by scratch testing. Corrosion resistance was evaluated using Tafel plots in Ringer's solution by Electrochemical analyser (ECA), and dielectric properties were measured using Impedance analyser. Biocompatibility was examined by wettability tests, thrombogenicity, antioxidant test, antimicrobial investigation and MTT [3-(4, 5-dimethythiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay. The results show that Mn-HAP/Al<sub>2</sub>O<sub>3</sub> coatings exhibit superior properties as compared to pure HAP, alumina, and HAP/Al<sub>2</sub>O<sub>3</sub>. Mn-HAP showed enhanced crystallinity and grain refinement, leading to improved hardness of 1198 HV for Mn-HAP/Al<sub>2</sub>O<sub>3</sub> as compared to 39.84 HV for pure HAP and 1028 HV for HAP/Al<sub>2</sub>O<sub>3</sub>. The friction coefficient was found to be best in the Mn-HAP/Al<sub>2</sub>O<sub>3</sub> sample. Corrosion rate significantly decreases in Mn-HAP/Al<sub>2</sub>O<sub>3</sub> (1.63 <span><math><mo>±</mo></math></span> 0.28) mmpy after coating on alumina. In vitro studies demonstrated enhanced cell attachment, proliferation, and differentiation after Mn-HAP coating on alumina. Antimicrobial tests revealed improved resistance against <em>E. coli</em> and <em>S. aureus</em>, with Mn-HAP/Al<sub>2</sub>O<sub>3</sub> showing a larger zone of inhibition. The study concludes that 3 wt% Mn-HAP coatings deposited by RF magnetron sputtering hold great promise for enhancing the performance and longevity of hard tissue implants, paving the way for advanced biomedical applications.</div></div>","PeriodicalId":22009,"journal":{"name":"Surface & Coatings Technology","volume":"494 ","pages":"Article 131481"},"PeriodicalIF":5.3000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Improvement in bioactivity, hardness and friction resistance of 3 % manganese-doped hydroxyapatite coated on alumina using radio frequency magnetron sputtering\",\"authors\":\"Ranbir Kumar , Deep Shikha , Sanjay Kumar Sinha\",\"doi\":\"10.1016/j.surfcoat.2024.131481\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Hydroxyapatite (HAP) is a common hard tissue implant material known for its superior biocompatibility and osteoconductivity. However, its poor mechanical strength, brittleness and slow degradation limit the applications. This study explores the enhancement of HAP mechanical properties and bioactivity by coating 3 wt% manganese-doped HAP (Mn-HAP) on another inert biomaterial alumina (Mn-HAP/Al<sub>2</sub>O<sub>3</sub>) substrates using the RF magnetron sputtering technique. Characterization of these samples was performed using Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive X-ray Spectroscopy (EDS), Grazing Incidence X-ray Diffraction (GIXRD), Fourier Transform Infrared Spectroscopy (FTIR) and Brunauer-Emmett-Teller (BET) techniques. Mechanical property was assessed through Vicker's hardness and adhesion of the film was studied by scratch testing. Corrosion resistance was evaluated using Tafel plots in Ringer's solution by Electrochemical analyser (ECA), and dielectric properties were measured using Impedance analyser. Biocompatibility was examined by wettability tests, thrombogenicity, antioxidant test, antimicrobial investigation and MTT [3-(4, 5-dimethythiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay. The results show that Mn-HAP/Al<sub>2</sub>O<sub>3</sub> coatings exhibit superior properties as compared to pure HAP, alumina, and HAP/Al<sub>2</sub>O<sub>3</sub>. Mn-HAP showed enhanced crystallinity and grain refinement, leading to improved hardness of 1198 HV for Mn-HAP/Al<sub>2</sub>O<sub>3</sub> as compared to 39.84 HV for pure HAP and 1028 HV for HAP/Al<sub>2</sub>O<sub>3</sub>. The friction coefficient was found to be best in the Mn-HAP/Al<sub>2</sub>O<sub>3</sub> sample. Corrosion rate significantly decreases in Mn-HAP/Al<sub>2</sub>O<sub>3</sub> (1.63 <span><math><mo>±</mo></math></span> 0.28) mmpy after coating on alumina. In vitro studies demonstrated enhanced cell attachment, proliferation, and differentiation after Mn-HAP coating on alumina. Antimicrobial tests revealed improved resistance against <em>E. coli</em> and <em>S. aureus</em>, with Mn-HAP/Al<sub>2</sub>O<sub>3</sub> showing a larger zone of inhibition. The study concludes that 3 wt% Mn-HAP coatings deposited by RF magnetron sputtering hold great promise for enhancing the performance and longevity of hard tissue implants, paving the way for advanced biomedical applications.</div></div>\",\"PeriodicalId\":22009,\"journal\":{\"name\":\"Surface & Coatings Technology\",\"volume\":\"494 \",\"pages\":\"Article 131481\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2024-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Surface & Coatings Technology\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0257897224011125\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, COATINGS & FILMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surface & Coatings Technology","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0257897224011125","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, COATINGS & FILMS","Score":null,"Total":0}
Improvement in bioactivity, hardness and friction resistance of 3 % manganese-doped hydroxyapatite coated on alumina using radio frequency magnetron sputtering
Hydroxyapatite (HAP) is a common hard tissue implant material known for its superior biocompatibility and osteoconductivity. However, its poor mechanical strength, brittleness and slow degradation limit the applications. This study explores the enhancement of HAP mechanical properties and bioactivity by coating 3 wt% manganese-doped HAP (Mn-HAP) on another inert biomaterial alumina (Mn-HAP/Al2O3) substrates using the RF magnetron sputtering technique. Characterization of these samples was performed using Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive X-ray Spectroscopy (EDS), Grazing Incidence X-ray Diffraction (GIXRD), Fourier Transform Infrared Spectroscopy (FTIR) and Brunauer-Emmett-Teller (BET) techniques. Mechanical property was assessed through Vicker's hardness and adhesion of the film was studied by scratch testing. Corrosion resistance was evaluated using Tafel plots in Ringer's solution by Electrochemical analyser (ECA), and dielectric properties were measured using Impedance analyser. Biocompatibility was examined by wettability tests, thrombogenicity, antioxidant test, antimicrobial investigation and MTT [3-(4, 5-dimethythiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay. The results show that Mn-HAP/Al2O3 coatings exhibit superior properties as compared to pure HAP, alumina, and HAP/Al2O3. Mn-HAP showed enhanced crystallinity and grain refinement, leading to improved hardness of 1198 HV for Mn-HAP/Al2O3 as compared to 39.84 HV for pure HAP and 1028 HV for HAP/Al2O3. The friction coefficient was found to be best in the Mn-HAP/Al2O3 sample. Corrosion rate significantly decreases in Mn-HAP/Al2O3 (1.63 0.28) mmpy after coating on alumina. In vitro studies demonstrated enhanced cell attachment, proliferation, and differentiation after Mn-HAP coating on alumina. Antimicrobial tests revealed improved resistance against E. coli and S. aureus, with Mn-HAP/Al2O3 showing a larger zone of inhibition. The study concludes that 3 wt% Mn-HAP coatings deposited by RF magnetron sputtering hold great promise for enhancing the performance and longevity of hard tissue implants, paving the way for advanced biomedical applications.
期刊介绍：
Surface and Coatings Technology is an international archival journal publishing scientific papers on significant developments in surface and interface engineering to modify and improve the surface properties of materials for protection in demanding contact conditions or aggressive environments, or for enhanced functional performance. Contributions range from original scientific articles concerned with fundamental and applied aspects of research or direct applications of metallic, inorganic, organic and composite coatings, to invited reviews of current technology in specific areas. Papers submitted to this journal are expected to be in line with the following aspects in processes, and properties/performance:
A. Processes: Physical and chemical vapour deposition techniques, thermal and plasma spraying, surface modification by directed energy techniques such as ion, electron and laser beams, thermo-chemical treatment, wet chemical and electrochemical processes such as plating, sol-gel coating, anodization, plasma electrolytic oxidation, etc., but excluding painting.
B. Properties/performance: friction performance, wear resistance (e.g., abrasion, erosion, fretting, etc), corrosion and oxidation resistance, thermal protection, diffusion resistance, hydrophilicity/hydrophobicity, and properties relevant to smart materials behaviour and enhanced multifunctional performance for environmental, energy and medical applications, but excluding device aspects.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
