高压介导的 1,2-二取代环丁烷衍生物片段库合成

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC European Journal of Organic Chemistry Pub Date : 2024-10-29 DOI:10.1002/ejoc.202400797

Mathilde A. C. H. Janssen, Rico Rappard, Tom Dekker, Mitchel Heiming, Marjolijn Beens, Dyon Pieters, Brian H. M. Kuijpers, Jorg C. J. Benningshof, Maikel Wijtmans, Iwan J. P. de Esch, Daniel Blanco-Ania, Floris P. J. T. Rutjes

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引用次数: 0

摘要

环丁烷因其独特的结构和潜在的药理特性优势，在药物化学领域引起了极大的兴趣。本研究以乙烯磺酰氟和叔丁基乙烯基醚之间的高压[2+2]环加成反应为关键步骤，合成了一个具有氨基甲酸酯或三唑的环丁烷磺酰胺类化合物的双扩散点文库。

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High-Pressure-Mediated Fragment Library Synthesis of 1,2-Disubsituted Cyclobutane Derivatives

Cyclobutanes have attracted significant interest in medicinal chemistry because of their unique structure and potential advantages in pharmacological properties. In this study a two-diversification-point library of cyclobutanesulfonamides with either carbamates or triazoles was synthesized through a hyperbaric [2+2] cycloaddition reaction between ethenesulfonyl fluoride and tert-butyl vinyl ether as the key step.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.