食用菌 Isaria cicadae Miquel 对 BALB/c 小鼠由葡聚糖硫酸钠诱发的溃疡性结肠炎有抑制作用

IF 5.2 Q1 FOOD SCIENCE & TECHNOLOGY Journal of Future Foods Pub Date : 2024-10-29 DOI:10.1016/j.jfutfo.2024.07.018
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引用次数: 0

摘要

蝉蜕(Isaria cicadae Miquel,IcM)是一种用于传统中药的食用菌。在这项研究中,我们采用经典分析方法鉴定了茨菇的营养成分,并在葡聚糖硫酸钠(DSS)诱导的溃疡性结肠炎(UC)小鼠模型中研究了茨菇对肠道粘膜炎症缓解和修复能力的保护作用和机制。IcM、美沙拉嗪单药或联合用药均能显著减轻结肠病理损伤,下调炎症因子(抗肿瘤坏死因子α(TNF-α)、白细胞介素-1β(IL-1β)、高迁移率组盒 1(HMGB1)、活化 B 细胞的核因子卡巴轻链增强因子(NF-κB)、分泌型免疫球蛋白 A(SIgA)),并改善 UC 的严重程度、通过调节糖皮质激素受体(GR)与 Hippo 通路关键蛋白之间的相互作用,并通过增加粘蛋白 2(MUC2)、Occludin、zonula occluden-1 (ZO-1)和 E-cadherin 的表达重塑肠粘膜屏障组织结构,以剂量依赖的方式改善 UC 的严重程度,而大剂量 IcM 治疗则会显著增加 UC 的严重程度。此外,IcM 和美沙拉嗪具有协同作用,可减弱对肝脏和肾脏的毒性,有助于缓解临床患者的病程。
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Isaria cicadae Miquel, as an edible fungus, against dextran sulfate sodium -induced ulcerative colitis in BALB/c mice
Isaria cicadae Miquel (IcM) is an edible fungus used in traditional Chinese medicine. In this study, we identified the nutritional components of IcM using classical analytical methods and investigated the protective effects and mechanisms of intestinal mucosal inflammation mitigation and repair capacity in a dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) mouse model. IcM, mesalazine alone, and co-administration significantly reduced colonic pathological damage, downregulated inflammatory factors (anti-tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), high mobility group box 1 (HMGB1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), secretory immunoglobulin A (SIgA)), and improved the severity of UC in a dose-dependent manner by regulating the interaction between glucocoriticoid receptor (GR) and key proteins in the Hippo pathway, remodeling the intestinal mucosal barrier tissue structure by increasing the expression of mucin 2 (MUC2), Occludin, zonula occluden-1 (ZO-1), and E-cadherin, whereas high-dose IcM treatment increased significantly. Moreover, IcM and mesalazine have a synergistic effect, weaken toxicity to the liver and kidney, and contribute to alleviating the disease process in clinical patients.
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