{"title":"评估老年保护疗法疗效的衰老生物标志物：问题与前景","authors":"O. Y. Rybina, E. G. Pasyukova","doi":"10.1134/S2635167624601104","DOIUrl":null,"url":null,"abstract":"<p>Biomarkers are biological indicators that may be used to evaluate the functional status of an organism, monitor the aging process, and predict the transition of it to a pathological state. Age-related changes in gene expression determine the development of specific age-related phenotypes considered as biomarkers of aging, such as changes in chromatin structure, loss of proteostasis, mitochondrial dysfunction, impaired intercellular communication, chronic inflammation, and imbalances in nutrient uptake. Aging biomarkers are considered to be essential in developing techniques to assess the efficacy of geroprotective treatments. In this context, assessment of the possibility, feasibility, and limitations of the practical use of biomarkers requires a thorough understanding of their molecular nature and careful evidence of their objective association with aging and lifespan. The review considers the data on the effectiveness of the influence of several geroprotectors on aging biomarkers and the lifespan of model organisms and discusses the prospects for using biomarkers of aging to evaluate the efficacy of drug therapy for aging.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 3","pages":"318 - 328"},"PeriodicalIF":0.8000,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aging Biomarkers in Assessing the Efficacy of Geroprotective Therapy: Problems and Prospects\",\"authors\":\"O. Y. Rybina, E. G. Pasyukova\",\"doi\":\"10.1134/S2635167624601104\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Biomarkers are biological indicators that may be used to evaluate the functional status of an organism, monitor the aging process, and predict the transition of it to a pathological state. Age-related changes in gene expression determine the development of specific age-related phenotypes considered as biomarkers of aging, such as changes in chromatin structure, loss of proteostasis, mitochondrial dysfunction, impaired intercellular communication, chronic inflammation, and imbalances in nutrient uptake. Aging biomarkers are considered to be essential in developing techniques to assess the efficacy of geroprotective treatments. In this context, assessment of the possibility, feasibility, and limitations of the practical use of biomarkers requires a thorough understanding of their molecular nature and careful evidence of their objective association with aging and lifespan. The review considers the data on the effectiveness of the influence of several geroprotectors on aging biomarkers and the lifespan of model organisms and discusses the prospects for using biomarkers of aging to evaluate the efficacy of drug therapy for aging.</p>\",\"PeriodicalId\":716,\"journal\":{\"name\":\"Nanotechnologies in Russia\",\"volume\":\"19 3\",\"pages\":\"318 - 328\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-10-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanotechnologies in Russia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S2635167624601104\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanotechnologies in Russia","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1134/S2635167624601104","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Engineering","Score":null,"Total":0}
Aging Biomarkers in Assessing the Efficacy of Geroprotective Therapy: Problems and Prospects
Biomarkers are biological indicators that may be used to evaluate the functional status of an organism, monitor the aging process, and predict the transition of it to a pathological state. Age-related changes in gene expression determine the development of specific age-related phenotypes considered as biomarkers of aging, such as changes in chromatin structure, loss of proteostasis, mitochondrial dysfunction, impaired intercellular communication, chronic inflammation, and imbalances in nutrient uptake. Aging biomarkers are considered to be essential in developing techniques to assess the efficacy of geroprotective treatments. In this context, assessment of the possibility, feasibility, and limitations of the practical use of biomarkers requires a thorough understanding of their molecular nature and careful evidence of their objective association with aging and lifespan. The review considers the data on the effectiveness of the influence of several geroprotectors on aging biomarkers and the lifespan of model organisms and discusses the prospects for using biomarkers of aging to evaluate the efficacy of drug therapy for aging.
期刊介绍：
Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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