A. I. Kulebyakina, I. A. Ivanov, K. T. Kalinin, P. V. Dmitryakov, A. N. Veleshko, K. V. Kondratyev, E. N. Poznyrev, T. E. Grigoriev, R. A. Aliev, S. N. Chvalun
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Influence of Gamma Radiation on the Stability and Properties of Poly(Lactide-Glycolide) Nanoparticles in an Aqueous Dispersion
Studying the effect of radiation on the stability and properties of nanoparticles is an important step in the development of drug delivery systems and radiopharmaceuticals. This work investigates the effect of gamma radiation with a total dose from 3 to 127 kGy on aqueous dispersions of poly(lactide-co-glycolic acid) (PLGA) nanoparticles stabilized with polyvinyl alcohol (PVA). It is found that after irradiation with doses up to 20 kGy, destruction occurs rapidly, and then it slows down. At the same time, the glass transition temperature of the PLGA core is practically unchanged and remains in the range of 37–38°C. The hydrodynamic diameter of the particles decreases due to the destruction of the PVA polymer chains. The hydrolysis of the irradiated and non-irradiated particles occurs at similar rates, which is probably explained by the glassy state of the core.
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Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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