1,2-Diones 与 3-氨基吡啶的反应

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY Russian Journal of General Chemistry Pub Date : 2024-10-29 DOI:10.1134/S1070363224090032

S. E. Vatolina, A. P. Krinochkin, A. A. Yurtaeva, A. S. Alekseeva, A. S. Markina, M. I. Valieva, V. V. Nadtochiy, O. V. Shabunina, D. S. Kopchuk, G. V. Zyryanov

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引用次数: 0

摘要

研究了 3-氨基吡啶与 9,10-菲醌和 1,2-萘醌在不同条件下的反应。观察到在起始二酮结构中存在一个额外的芳香环时，会形成单亚胺。在没有该附加环的情况下，得到了芳香环 C4 位氨基亲核攻击的产物。得到的产物之一是 Lawsone 的衍生物，这是一种天然染料，具有广泛的生物活性，包括抗肿瘤活性。此外，还通过单晶 X 射线衍射分析证实了它的结构。

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Reactions of 1,2-Diones with 3-Aminopyridine

The reactions of 3-aminopyridine with 9,10-phenanthrenequinone and 1,2-naphthoquinone under various conditions was studied. The formation of the monoimine was observed in the presence of an additional aromatic ring in the structure of the starting dione. The product of the nucleophilic attack of the amino group at position C4 of the aromatic ring was obtained in the absence of this additional ring. One of the products obtained is a derivative of lawsone, a natural dye with a wide range of bioactivity, including antitumor one. Its structure was additionally confirmed by single crystal X-ray diffraction analysis.

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.