封底内页超分子自组装纳米粒子通过增强心肌细胞有丝分裂靶向治疗心肌梗死

IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY Aggregate (Hoboken, N.J.) Pub Date : 2024-10-20 DOI:10.1002/agt2.683
Yang Jiao, Haimang Wang, Xiechuan Weng, Jihang Wang, Ying Li, Jian Shen, Weiwei Zhao, Qing Xi, Hongyu Zhang, Zhenhong Fu
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引用次数: 0

摘要

本研究开发了具有巨噬细胞逃逸、心脏靶向和药物释放等多功能特性的超分子自组装纳米粒子,用于治疗心肌梗死。该纳米粒子可减少心肌细胞凋亡,减轻心肌间质纤维化,并基于增强有丝分裂和减轻线粒体损伤的机制增强心脏功能(e563)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Inside Back Cover: Supramolecular self-assembled nanoparticles for targeted therapy of myocardial infarction by enhancing cardiomyocyte mitophagy

In this study, supramolecular self-assembled nanoparticles were developed with multi-functional properties of macrophage escape, cardiac targeting, and drug release for the treatment of myocardial infarction. The nanoparticles reduced cardiomyocyte apoptosis, alleviated myocardial interstitial fibrosis, and enhanced cardiac function based on the mechanism of the enhancement in mitophagy and alleviation in mitochondrial damage (e563).

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CiteScore
17.40
自引率
0.00%
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审稿时长
7 weeks
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Issue Information Inside Front Cover: Stimuli-responsive photoluminescent copper(I) halides for scintillation, anticounterfeiting, and light-emitting diode applications Inside Back Cover: Supramolecular self-assembled nanoparticles for targeted therapy of myocardial infarction by enhancing cardiomyocyte mitophagy Front Cover: Steric hindrance induced low exciton binding energy enables low-driving-force organic solar cells Back Cover: Lysine aggregates-based nanostructured antimicrobial peptides for cariogenic biofilm microenvironment-activated caries treatment
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