Aggregate (Hoboken, N.J.)最新文献

This article focuses on the regulation of steric hindrance effect on the exciton binding energy of Y-series non-fullerene acceptors. The introduction of bulk cyclohexyl group in the side chains modulates inter- and intramolecular interactions of acceptors, thereby influencing the exciton binding energy and ultimately enhancing the energy conversion efficiency of organic solar cells (e632).

Aggregated lysine mimics antimicrobial peptides (AMPs) by disrupting bacterial membranes, interfering with metabolism, and inhibiting protein synthesis. With Fe³⁺ hydrolysis, lysine coordination, and ultrasmall Au nanoparticle deposition, FeOOH@Fe-Lysine@Au shows AMP-like antibacterial activity and reactive oxygen species generation, providing an effective approach for cariogenic biofilm microenvironment-activated caries treatment (e578).

Near unity photoluminescence efficiency has been achieved in green emitting (TEP)₂Cu₂Br₄ and orange emitting (TEP)₂Cu₄Br₆. In both cases, emission originates from self-trapped excitons localized on the copper(I) halide structural units. The sensitivity of these compounds to the external stimuli coupled with their ultrabright emission allows their consideration for applications such as solid-state lighting, scintillation, sensing, information storage, and anticounterfeiting (e602).

In this study, supramolecular self-assembled nanoparticles were developed with multi-functional properties of macrophage escape, cardiac targeting, and drug release for the treatment of myocardial infarction. The nanoparticles reduced cardiomyocyte apoptosis, alleviated myocardial interstitial fibrosis, and enhanced cardiac function based on the mechanism of the enhancement in mitophagy and alleviation in mitochondrial damage (e563).

In the newly developed MSS-RCA technique, a circular template with minimal secondary structure was designed to achieve the higher amplification efficiency compared with conventional RCA technique. The linear structure of the MSS-RCA product provides the highest signal binding efficiency. Integration with a blood glucose meter, MSS-RCA technique was suitable for point-of-care detection of HPV mRNA for cervical cancer screening (e569).

Aggregation and aging of nanoparticle–protein complexes at interfaces are resolved via an evanescent-light scattering microscopy. Time- and space-resolved measurements by correlation functions show that aging of such soft materials is out-of-equilibrium, stretched and compressed exponential decays can coexist in one aging process. Corona formation, inner stress and inter-connection are key for the aggregation and aging dynamics (e538).

This paper focuses on the aggregation effects on the reactive oxygen species generation, highlighting the significant variations among isolated and various nano-aggregated states. It provides a consolidated overview on the fundamental principles, discusses current research methodologies, and reviews present research status concerning the aggregation effects on ROS generation, aiming to drive continuous progress in aggregate-level phototheranostic platforms (e540).

This study identifies metabolic reprogramming and immunosuppression as key factors in transarterial chemoembolization (TACE) refractoriness. Rhein is optimized as a glycolytic inhibitor and immunoactivator to enhance tumor response to TACE. An oil-in-water lipiodol emulsion stabilized with Rhein nanogel holds enhanced mechanical stability, ensuring effective embolization, prolonged drug release, and potent anti-tumor immunity, presenting a new approach for TACE (e552).

Efficient strategies for transforming Bacillus subtilis vegetative cells into spores (BtS transformation) are still limited, although they show promise for the treatment of inflammatory bowel disease (IBD). A novel, simple, and rapid photo-induced BtS transformation mechanism is now presented that utilizes a novel aggregation-induced emission luminogen (AIEgen) photosensitizer, triphenylamine-benzothiadiazole-pyridine-p-tolylboronic acid bromine salt (TBPBB), that generates reactive oxygen species (ROS) when exposed to light. The ROS selectively target and damage the membranes of Bacillus subtilis and trigger their transformation into spores. These spores demonstrate considerable promise for the effective treatment of IBD in a mouse disease model. Furthermore, the fluorescence signal generated by TBPBB can be used to directly visualize the recovery of damaged intestinal tissue. This is a valuable tool for monitoring the healing process and gaining insights into therapeutic efficacy. This study highlights the remarkable practical value of AIEgen-induced BtS transformation for identifying, localizing, and visualizing the therapeutic outcomes of IBD treatments.

Exciton binding energy (E_b) has been regarded as a critical parameter in charge separation during photovoltaic conversion. Minimizing the E_b of the photovoltaic materials can facilitate the exciton dissociation in low-driving force organic solar cells (OSCs) and thus improve the power conversion efficiency (PCE); nevertheless, diminishing the E_b with deliberate design principles remains a significant challenge. Herein, bulky side chain as steric hindrance structure was inserted into Y-series acceptors to minimize the E_b by modulating the intra- and intermolecular interaction. Theoretical and experimental results indicate that steric hindrance-induced optimal intra- and intermolecular interaction can enhance molecular polarizability, promote electronic orbital overlap between molecules, and facilitate delocalized charge transfer pathways, thereby resulting in a low E_b. The conspicuously reduced E_b obtained in Y-ChC5 with pinpoint steric hindrance modulation can minimize the detrimental effects on exciton dissociation in low-driving-force OSCs, achieving a remarkable PCE of 19.1% with over 95% internal quantum efficiency. Our study provides a new molecular design rationale to reduce the E_b.