Aggregate (Hoboken, N.J.)最新文献

As compared with their well-known behaviors in aqueous solutions, organic fluorescent probes with saturated aliphatic chains exhibit different patterns of self-coiling and aggregation behaviors in polar fluorinated arenes. Possible reasons for these differences are discussed in this report. And the insights revealed in this work can be applied as guidelines for macrolactonization reaction optimization (e70160).

Microgels are an emerging and highly promising material for biofabrication, distinguished by their highly tunable structures and multifunctional properties. They are thus positioned as a compelling alternative to conventional bulk hydrogels. This review provides a critical overview of the key advances in microgel fabrication technologies, their material characteristics, and their burgeoning applications in tissue engineering and regenerative medicine (e70166).

This review elucidates the multiscale coupling between macroscopic mechanics and atomic assembly during halide perovskite crystallization. It emphasizes how surface tension, fluid dynamics, and interfacial stresses govern solute aggregation and crystal growth, thereby suppressing defects and enabling the formation of highly ordered, high-quality films. These mechanistic insights establish a foundational framework for the scalable fabrication of next-generation optoelectronic technologies (e70170).

A multi-stimuli-responsive Pd₂L₄ metallacage (MC) is designed through the self-assembly of triphenylamine-based dipyridyl ligands and Pd(II) ions. MC undergoes reversible assembly/disassembly, showing FRET emission enhancement and selective gelation with naphthalene disulfonates. It rapidly and selectively detects cysteine (LOD 1.22 × 10⁻⁶ M) through fluorescence changes triggered by a self-destruction mechanism and has been applied in test strips (e70144).

Gliomas present a significant challenge in oncology due to their often subtle early symptoms and the insidious nature of their growth, which is compounded by the blood–brain barrier. Recent evidence has highlighted the diagnostic and therapeutic potential of monocytes, macrophages, and microglia in the context of glioma. This review focused on emerging evidence and hypotheses concerning the components and interrelationships within the mononuclear phagocyte system (MPS) in the central nervous system and its role in glioma development and invasion. By summarizing the involvement of the MPS in glioma biology, this paper offers a novel perspective for the integration of liquid biopsy and targeted therapies in oncology.

The rational design of aqueous-phase supramolecular catalysts that integrate substrate recognition, activation, reaction selectivity, and recyclability remains a significant challenge. This work presents a cucurbit[8]uril (Q[8])-based supramolecular photocatalyst, TMV⁸⁺@Q[8], which selectively encapsulates aromatic sulfide substrates via host-stabilized charge transfer (HSCT) interactions while markedly enhancing singlet oxygen (¹O₂) generation. Under visible-light irradiation, the substrate-TMV⁸⁺@Q[8] system facilitates the efficient catalytic oxidation of aromatic sulfides to sulfoxides. Competitive displacement experiments confirm that product desorption is substrate-driven, enabling catalyst regeneration. Crucially, the Q[8] cavity plays a multifaceted role by enhancing substrate activation through HSCT, promoting ¹O₂-mediated oxidation via confinement effects, and enforcing selectivity through size exclusion. These findings establish a new paradigm for supramolecular photocatalysis, wherein macrocyclic confinement concurrently enhances substrate recognition, catalytic efficiency, and recyclability. This study thereby provides a strategic blueprint for designing enzyme-inspired supramolecular photocatalysts operable in aqueous media.

The aggregation of α-synuclein (ɑ-syn) coupled with overexpressed neuroinflammation instigates the degeneration of dopaminergic neurons, thereby aggravating the progression of Parkinson's disease (PD). Herein, we introduced a series of hydrophobic amino acid-based carbon dots (CDs) for inhibiting ɑ-syn aggregation and mitigating the inflammation in PD neurons. Significantly, we show that phenylalanine CDs (Phe-CDs) could strongly bind with ɑ-syn monomers and dimers via hydrophobic force, maintain their stability, and inhibit their further aggregation in situ and in vitro, finally conferring neuroprotection in PD by rescuing synaptic loss, ameliorating mitochondrial dysfunctions, and modulating Ca²⁺ flux. Importantly, Phe-CDs demonstrate the ability to penetrate the blood–brain barrier, significantly improving motor performance in PD mice. Our findings suggest that Phe-CDs hold great promise as a therapeutic agent for PD and the related neurodegenerative disease.

Nuclease nanozymes promise robust, tailorable alternatives to natural nucleases, but suffer from their limited hydrolytic activity due to the Lewis acidity-centric mechanistic dogma and the unclear role of nanozyme–DNA interactions. Here, we report an affinity-driven strategy that upends conventional cognition. A series of lanthanide metal-organic frameworks (Ln-MOFs) were constructed, with catalytic efficiency decoupled from simple acid strength. Activity increased with the lanthanide atomic number despite a decrease in nanozyme-DNA affinity. Among these, Yb-BDC (terephthalic acid-based) exhibited the highest DNA-cleaving efficiency reported to date (half-life ≈ 30 min), yet showed minimal activity toward the traditional model substrate bis(4-nitrophenyl) phosphate (BNPP), thereby challenging the conventional Lewis acidity-driven paradigm. This unexpected inverse relationship reveals a critical binding-release cycle as the true driver of DNA hydrolysis. Capitalizing on this discovery, we developed a synthetic CRISPR/Cas-inspired biosensing platform by integrating Yb-BDC with rolling circle amplification, replacing natural nucleases. This system enables ultrasensitive detection of non-nucleic acid targets, expanding the scope of nanozymes in diagnostic applications. Our findings not only establish host–guest interaction engineering as a new paradigm for nuclease nanozymes design but also pioneer a modular framework for their application in biosensing technologies.

Organic electronic devices offer unique advantages in flexible, solution-processable, and cost-effective applications, where molecular stacking directly determines the optoelectronic properties of materials and devices. Heterojunction microstructures, which serve as the fundamental building blocks for controlling photoexciton dynamics and charge transport processes, have emerged as a critical feature to govern the coordination of exciton dynamics, charge transport, and multifunctional coupling in organic semiconductors. In this review, we provide a comprehensive overview of recent advances in heterojunction microstructures for modulating optoelectronic properties, offering valuable insights for high-performance and multifunctional organic electronics applications. We begin by introducing the fundamentals of heterojunction aggregation and its role in modulating physical processes through electronic structure and carrier transport engineering. Subsequently, we review recent progress in heterojunction aggregation within organic electronics, encompassing performance optimization and multifunctional extensions. In addition, we summarize four key strategies for constructing heterojunction microstructures in organic electronic devices. Finally, we outline future perspectives, emphasizing the critical need for deeper understanding of aggregation dynamics and the development of scalable fabrication approaches for heterojunction-structured films in next-generation intelligent devices.

Engineered RNA devices can identify disease-specific markers and precisely regulate gene expression, which is of great significance to the development of precision medicine. Some studies are shifting the focus from systemic drug delivery to precise gene regulation. A series of targeted delivery technologies has achieved enrichment of RNA drugs in specific tissues/organs. However, the limited cellular selectivity of RNA remains a major obstacle to progress in this field. The cellular precise regulation still requires much improvement. In recent years, advances in synthetic biology have facilitated the development of various RNA devices capable of specifically recognizing intracellular transcripts, proteins, and microRNAs. Nevertheless, the application of these tools remains largely restricted to in vitro cell detection and cell fate manipulation, due to insufficient cross-disciplinary collaboration. Therefore, given the advantages of advanced delivery technologies, combined with the RNA devices that enable precise regulation of gene expression at the cellular level, now is an opportune moment to integrate these RNA devices with state-of-the-art delivery platforms. Such integration promises to enhance the efficacy of engineered RNA devices for precise in vivo targeted therapeutics. In this review, we highlight examples of the advances and current limitations of RNA devices, including toehold switches, microRNAs, and ADAR (adenosine deaminase acting on RNA) sensors for precision disease treatment via advanced delivery systems. These considerations are essential to develop strategies for the targeted therapeutic exploitation of RNA device-based and delivery systems as a powerful programmable biological platform. Furthermore, we will assess the current maturity of RNA device technology and identify emerging innovation areas expected to drive significant future progress.