This review focuses on the lipid droplets (LDs)-localized chemical chromophores for photodynamic therapy. It highlights the design principles, performance, and biomedical applications of these photosensitizers (PSs). Especially, the cell death pathways induced by these tools are introduced. These targetable PSs guard our health by destroying the LDs of cancer cells, just as soldiers protect our cities from alien invasion by destroying the energy cores of alien airships (e665).
This study provides a novel molecular design methodology that dramatically decreases the isotropization temperature of π-conjugated nematic liquid crystals (NLC). In addition, a large-area electric-field-responsive fluorescent switch device with a sub-millisecond response time is demonstrated using a luminescent NLC and a liquid crystal display cell. The era of alignment of liquid crystalline organic semiconductors as desired has begun (e660).
A counterintuitive optimized dilution effect is unveiled for conjugated polymers in blends. In partially miscible blends, these polymers are more dilute in the majority phase; however, in fully miscible blends, the high miscibility fosters extended chain conformations that undermine dilution. These revelations will inform the design of future generations of polymer light-emitting diodes (e649).
This study identified circWDR37 as a promising biomarker for the early diagnosis and prognostic prediction of colorectal cancer (CRC). A detection platform, termed μDCR, was developed utilizing polyethylene glycol 8000 and dextran-10 to enhance fluorescence and improve detection sensitivity. It is anticipated that μDCR will serve as an optimal method for noninvasive CRC screening (e663).
The rising popularity of photosensitizers has greatly transformed traditional cancer diagnosis and phototherapeutic strategies. This review highlights the latest advances in small molecule photosensitizers with aggregation-induced emission (AIE) for cancer theranostics, following the principle of “Complexity made easy.” This study emphasizes on simplicity, expeditiousness, and safety, as it aims to advance cancer research (e657).
The formation, assembly and jamming of nanoparticle surfactants (NPS) by the co-assembly between polydopamine nanoparticles and poly(styrene-co-methacrylamidophenylboronic acid) at the oil-water interface is presented. Taking advantage of the photothermal property of PDA NPs, the thermal responsiveness of NPSs can be triggered upon near-infrared irradiation, allowing the welding of droplets and offering a straightforward to construct modular droplet devices (e621).
The constructive chemical combination of iridium(III) complexes and C60 moiety endows Ir-C601 with dual reactive oxygen species (ROS) regulation abilities and promising antitumor photo-immunotherapeutic activities. In the dark, Ir-C601 serves as ROS scavengers to reverse dysfunctional T cells. Upon photo irradiation, Ir-C601 can produce various ROS and oxidize tubulin to exert efficient photo-immunotherapeutic effects through multiple antitumor pathways (e623).
In the current work, superparamagnetic iron oxide nanoparticles coated with zwitterionic ligands improved cell loading and retention for Magnetic Particle Imaging. The best-performing surface coating enabled high cell uptake with short incubation times and stable in vivo imaging over 7 days. These advancements improve the sensitivity and duration of cell tracking by enhancing nanoparticle loading into a variety of cell types (e609).
This article focuses on the regulation of steric hindrance effect on the exciton binding energy of Y-series non-fullerene acceptors. The introduction of bulk cyclohexyl group in the side chains modulates inter- and intramolecular interactions of acceptors, thereby influencing the exciton binding energy and ultimately enhancing the energy conversion efficiency of organic solar cells (e632).
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