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Front Cover: Steric hindrance induced low exciton binding energy enables low-driving-force organic solar cells 封面:立体阻碍诱导的低激子结合能可实现低驱动力有机太阳能电池
IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-20 DOI: 10.1002/agt2.681
Tianyu Hu, Xufan Zheng, Ting Wang, Aziz Saparbaev, Bowen Gao, Jingnan Wu, Jingyi Xiong, Ming Wan, Tingting Cong, Yuda Li, Ergang Wang, Xunchang Wang, Renqiang Yang

This article focuses on the regulation of steric hindrance effect on the exciton binding energy of Y-series non-fullerene acceptors. The introduction of bulk cyclohexyl group in the side chains modulates inter- and intramolecular interactions of acceptors, thereby influencing the exciton binding energy and ultimately enhancing the energy conversion efficiency of organic solar cells (e632).

本文重点研究了立体阻碍效应对 Y 系列非富勒烯受体的激子结合能的调节。在侧链中引入大量环己基可以调节受体的分子间和分子内相互作用,从而影响激子结合能,最终提高有机太阳能电池的能量转换效率 (e632)。
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引用次数: 0
Back Cover: Lysine aggregates-based nanostructured antimicrobial peptides for cariogenic biofilm microenvironment-activated caries treatment 封底:基于赖氨酸聚合体的纳米结构抗菌肽用于致龋生物膜微环境激活型龋病治疗
IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-20 DOI: 10.1002/agt2.684
Siyuan Li, Feng Wang, Yang Chen, Wanrui Shi, Dashuai Liu, Mingyang Lv, Bin Zhao, Yi Liu, Hao Zhang

Aggregated lysine mimics antimicrobial peptides (AMPs) by disrupting bacterial membranes, interfering with metabolism, and inhibiting protein synthesis. With Fe3+ hydrolysis, lysine coordination, and ultrasmall Au nanoparticle deposition, FeOOH@Fe-Lysine@Au shows AMP-like antibacterial activity and reactive oxygen species generation, providing an effective approach for cariogenic biofilm microenvironment-activated caries treatment (e578).

聚合赖氨酸通过破坏细菌膜、干扰新陈代谢和抑制蛋白质合成来模拟抗菌肽(AMPs)。通过 Fe3+ 水解、赖氨酸配位和超小金纳米粒子沉积,FeOOH@Fe-赖氨酸@金显示出类似于 AMP 的抗菌活性和活性氧生成,为龋病生物膜微环境激活型龋病治疗提供了一种有效的方法 (e578)。
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引用次数: 0
Inside Front Cover: Stimuli-responsive photoluminescent copper(I) halides for scintillation, anticounterfeiting, and light-emitting diode applications 封面内页:用于闪烁、防伪和发光二极管的刺激响应型光致发光铜(I)卤化物
IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-20 DOI: 10.1002/agt2.682
Dilruba A. Popy, Yashpal Singh, Yauhen Tratsiak, Abby M. Cardoza, John M. Lane, Luis Stand, Mariya Zhuravleva, Neeraj Rai, Bayram Saparov

Near unity photoluminescence efficiency has been achieved in green emitting (TEP)2Cu2Br4 and orange emitting (TEP)2Cu4Br6. In both cases, emission originates from self-trapped excitons localized on the copper(I) halide structural units. The sensitivity of these compounds to the external stimuli coupled with their ultrabright emission allows their consideration for applications such as solid-state lighting, scintillation, sensing, information storage, and anticounterfeiting (e602).

绿色发光的 (TEP)2Cu2Br4 和橙色发光的 (TEP)2Cu4Br6 的光致发光效率已接近统一。在这两种情况下,发射都源于卤化铜(I)结构单元上定位的自俘获激子。这些化合物对外部刺激的敏感性及其超亮的发射使它们可以被考虑用于固态照明、闪烁、传感、信息存储和防伪等领域 (e602)。
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引用次数: 0
Inside Back Cover: Supramolecular self-assembled nanoparticles for targeted therapy of myocardial infarction by enhancing cardiomyocyte mitophagy 封底内页超分子自组装纳米粒子通过增强心肌细胞有丝分裂靶向治疗心肌梗死
IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-20 DOI: 10.1002/agt2.683
Yang Jiao, Haimang Wang, Xiechuan Weng, Jihang Wang, Ying Li, Jian Shen, Weiwei Zhao, Qing Xi, Hongyu Zhang, Zhenhong Fu

In this study, supramolecular self-assembled nanoparticles were developed with multi-functional properties of macrophage escape, cardiac targeting, and drug release for the treatment of myocardial infarction. The nanoparticles reduced cardiomyocyte apoptosis, alleviated myocardial interstitial fibrosis, and enhanced cardiac function based on the mechanism of the enhancement in mitophagy and alleviation in mitochondrial damage (e563).

本研究开发了具有巨噬细胞逃逸、心脏靶向和药物释放等多功能特性的超分子自组装纳米粒子,用于治疗心肌梗死。该纳米粒子可减少心肌细胞凋亡,减轻心肌间质纤维化,并基于增强有丝分裂和减轻线粒体损伤的机制增强心脏功能(e563)。
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引用次数: 0
Inside Back Cover: Aggregation and aging of nanoparticle–protein complexes at interfaces studied by evanescent-light scattering microscopy 封底内页:用渐变光散射显微镜研究纳米粒子-蛋白质复合物在界面上的聚集和老化现象
IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-08-20 DOI: 10.1002/agt2.655
Wei Liu, Yuwei Zhu, Hang Jiang, Lidan Zhou, Yinan Li, Jiahao Wu, Jie Han, Cheng Yang, Jianzhong Jiang, To Ngai

Aggregation and aging of nanoparticle–protein complexes at interfaces are resolved via an evanescent-light scattering microscopy. Time- and space-resolved measurements by correlation functions show that aging of such soft materials is out-of-equilibrium, stretched and compressed exponential decays can coexist in one aging process. Corona formation, inner stress and inter-connection are key for the aggregation and aging dynamics (e538).

通过渐变光散射显微镜解析了纳米粒子-蛋白质复合物在界面上的聚集和老化。通过相关函数进行的时间和空间分辨测量表明,这种软材料的老化是非均衡的,拉伸和压缩指数衰减可以共存于一个老化过程中。电晕形成、内应力和相互连接是聚集和老化动力学的关键 (e538)。
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引用次数: 0
Back Cover: Special RCA based sensitive point-of-care detection of HPV mRNA for cervical cancer screening 封底:基于特殊 RCA 的宫颈癌筛查 HPV mRNA 床旁灵敏检测技术
IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-08-20 DOI: 10.1002/agt2.656
Yi Long, Shurui Tao, Dongni Shi, Xingyu Jiang, Tian Yu, Yingxi Long, Libing Song, Guozhen Liu

In the newly developed MSS-RCA technique, a circular template with minimal secondary structure was designed to achieve the higher amplification efficiency compared with conventional RCA technique. The linear structure of the MSS-RCA product provides the highest signal binding efficiency. Integration with a blood glucose meter, MSS-RCA technique was suitable for point-of-care detection of HPV mRNA for cervical cancer screening (e569).

与传统的 RCA 技术相比,新开发的 MSS-RCA 技术设计了二级结构最小的环形模板,以实现更高的扩增效率。MSS-RCA 产品的线性结构提供了最高的信号结合效率。与血糖仪整合后,MSS-RCA 技术适用于宫颈癌筛查中的 HPV mRNA 护理点检测 (e569)。
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引用次数: 0
Inside Front Cover: Exploring and leveraging aggregation effects on reactive oxygen species generation in photodynamic therapy 封面内页:探索和利用光动力疗法中活性氧生成的聚集效应
IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-08-20 DOI: 10.1002/agt2.654
Zeyan Zhuang, Jianqing Li, Pingchuan Shen, Zujin Zhao, Ben Zhong Tang

This paper focuses on the aggregation effects on the reactive oxygen species generation, highlighting the significant variations among isolated and various nano-aggregated states. It provides a consolidated overview on the fundamental principles, discusses current research methodologies, and reviews present research status concerning the aggregation effects on ROS generation, aiming to drive continuous progress in aggregate-level phototheranostic platforms (e540).

本文重点关注聚集效应对活性氧生成的影响,突出孤立状态和各种纳米聚集状态之间的显著差异。它综合概述了基本原理,讨论了当前的研究方法,并回顾了有关聚集效应对活性氧生成的研究现状,旨在推动聚集级光otheranostic 平台(e540)的不断进步。
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引用次数: 0
Front Cover: Rhein-based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization 封面:治疗肝细胞癌的莱茵基皮克林乳剂:塑造经动脉化疗栓塞术中的代谢信号和免疫激活作用
IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-08-20 DOI: 10.1002/agt2.653
Xiaoliu Liang, Hui Liu, Hu Chen, Xuqi Peng, Zhenjie Li, Minglei Teng, Yisheng Peng, Jiwei Li, Linyu Ding, Jingsong Mao, Chengchao Chu, Hongwei Cheng, Gang Liu

This study identifies metabolic reprogramming and immunosuppression as key factors in transarterial chemoembolization (TACE) refractoriness. Rhein is optimized as a glycolytic inhibitor and immunoactivator to enhance tumor response to TACE. An oil-in-water lipiodol emulsion stabilized with Rhein nanogel holds enhanced mechanical stability, ensuring effective embolization, prolonged drug release, and potent anti-tumor immunity, presenting a new approach for TACE (e552).

这项研究发现,代谢重编程和免疫抑制是经动脉化疗栓塞术(TACE)难治性的关键因素。Rhein 作为一种糖酵解抑制剂和免疫激活剂被优化用于增强肿瘤对 TACE 的反应。用 Rhein 纳米凝胶稳定的水包油型脂碘乳剂具有更高的机械稳定性,可确保有效栓塞、延长药物释放时间和增强抗肿瘤免疫力,为 TACE 提供了一种新方法 (e552)。
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引用次数: 0
Photo-induced Bacillus subtilis-spore transformation for bowel disease therapy and therapeutic outcome visualization 光诱导枯草芽孢杆菌孢子转化用于肠道疾病治疗和疗效可视化
IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-02 DOI: 10.1002/agt2.597
Lin Kong, Wei He, Junyi Gong, Zijie Qiu, Zheng Zhao, Ben Zhong Tang

Efficient strategies for transforming Bacillus subtilis vegetative cells into spores (BtS transformation) are still limited, although they show promise for the treatment of inflammatory bowel disease (IBD). A novel, simple, and rapid photo-induced BtS transformation mechanism is now presented that utilizes a novel aggregation-induced emission luminogen (AIEgen) photosensitizer, triphenylamine-benzothiadiazole-pyridine-p-tolylboronic acid bromine salt (TBPBB), that generates reactive oxygen species (ROS) when exposed to light. The ROS selectively target and damage the membranes of Bacillus subtilis and trigger their transformation into spores. These spores demonstrate considerable promise for the effective treatment of IBD in a mouse disease model. Furthermore, the fluorescence signal generated by TBPBB can be used to directly visualize the recovery of damaged intestinal tissue. This is a valuable tool for monitoring the healing process and gaining insights into therapeutic efficacy. This study highlights the remarkable practical value of AIEgen-induced BtS transformation for identifying, localizing, and visualizing the therapeutic outcomes of IBD treatments.

将枯草芽孢杆菌无性细胞转化为孢子(BtS 转化)的有效策略仍然有限,尽管它们在治疗炎症性肠病(IBD)方面大有可为。现在介绍一种新颖、简单、快速的光诱导 BtS 转化机制,该机制利用一种新型聚集诱导发射发光剂(AIEgen)光敏剂,即三苯胺-苯并噻二唑-吡啶-对甲苯硼酸溴盐(TBPBB),在光照下会产生活性氧(ROS)。ROS 选择性地靶向破坏枯草芽孢杆菌的膜,并促使它们转化为芽孢。这些孢子在小鼠疾病模型中显示出有效治疗肠道疾病的巨大前景。此外,TBPBB 产生的荧光信号可用于直接观察受损肠道组织的恢复情况。这是监测愈合过程和深入了解疗效的重要工具。这项研究凸显了 AIEgen 诱导的 BtS 转化在识别、定位和可视化 IBD 治疗结果方面的显著实用价值。
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引用次数: 0
Steric hindrance induced low exciton binding energy enables low-driving-force organic solar cells 立体阻碍诱导的低激子结合能可实现低驱动力有机太阳能电池
IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-02 DOI: 10.1002/agt2.632
Tianyu Hu, Xufan Zheng, Ting Wang, Aziz Saparbaev, Bowen Gao, Jingnan Wu, Jingyi Xiong, Ming Wan, Tingting Cong, Yuda Li, Ergang Wang, Xunchang Wang, Renqiang Yang

Exciton binding energy (Eb) has been regarded as a critical parameter in charge separation during photovoltaic conversion. Minimizing the Eb of the photovoltaic materials can facilitate the exciton dissociation in low-driving force organic solar cells (OSCs) and thus improve the power conversion efficiency (PCE); nevertheless, diminishing the Eb with deliberate design principles remains a significant challenge. Herein, bulky side chain as steric hindrance structure was inserted into Y-series acceptors to minimize the Eb by modulating the intra- and intermolecular interaction. Theoretical and experimental results indicate that steric hindrance-induced optimal intra- and intermolecular interaction can enhance molecular polarizability, promote electronic orbital overlap between molecules, and facilitate delocalized charge transfer pathways, thereby resulting in a low Eb. The conspicuously reduced Eb obtained in Y-ChC5 with pinpoint steric hindrance modulation can minimize the detrimental effects on exciton dissociation in low-driving-force OSCs, achieving a remarkable PCE of 19.1% with over 95% internal quantum efficiency. Our study provides a new molecular design rationale to reduce the Eb.

激子结合能(Eb)一直被视为光电转换过程中电荷分离的关键参数。将光伏材料的 Eb 降到最低可以促进低驱动力有机太阳能电池(OSC)中激子的解离,从而提高功率转换效率(PCE);然而,通过深思熟虑的设计原则降低 Eb 仍然是一项重大挑战。在此,我们在 Y 系列受体中加入了作为立体阻碍结构的笨重侧链,通过调节分子内和分子间的相互作用将 Eb 降到最低。理论和实验结果表明,立体阻碍引起的最佳分子内和分子间相互作用可提高分子极化性,促进分子间电子轨道重叠,并促进电荷转移的非局域化途径,从而实现低 Eb。通过精确的立体阻碍调制,Y-ChC5 中的 Eb 明显降低,从而最大限度地减少了对低驱动力 OSC 中激子解离的不利影响,实现了 19.1% 的出色 PCE 和超过 95% 的内部量子效率。我们的研究为降低 Eb 提供了新的分子设计原理。
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