皮肤和皮下前列腺特异性膜抗原受体病变

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Clinical Nuclear Medicine Pub Date : 2025-03-01 Epub Date: 2024-10-30 DOI:10.1097/RLU.0000000000005525

Zahra Rafiei, Amin Saber Tanha, Naser Tayyebi Meibodi, Siavash Zahed Anaraki, Emran Askari

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引用次数: 0

摘要

摘要：我们报告了一例 62 岁男性转移性耐受性前列腺癌患者的病例，患者皮下受累，正在接受 177Lu 前列腺特异性膜抗原（PSMA）治疗。治疗前，他被诊断出胸壁有两个皮下结节，耻骨区和腹股沟区软组织水肿，显示 PSMA 阳性。活检和免疫组化评估证实了前列腺癌的皮肤转移。他接受了 3 个周期的 177Lu-PSMA 治疗，结果 PSA 水平下降，症状缓解。该病例凸显了前列腺癌皮肤转移诊断的挑战性，尤其是在非典型病例中。我们还回顾了皮肤和皮下组织中 PSMA-avid 病变的所有病因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cutaneous and Subcutaneous Prostate-Specific Membrane Antigen-Avid Lesions.

Abstract: We report the case of a 62-year-old man with metastatic castration-resistant prostate cancer with subcutaneous involvement being treated with 177 Lu-prostate-specific membrane antigen (PSMA). Before treatment, he was diagnosed with 2 subcutaneous nodules in the chest wall and soft tissue edema in the pubic and inguinal regions showing PSMA avidity. Biopsy and immunohistochemistry assessment confirmed cutaneous metastases from prostate cancer. He received 3 cycles of 177 Lu-PSMA, resulting in a decline in PSA levels and resolution of symptoms. This case underscores the challenging diagnosis of cutaneous metastasis from prostate cancer, especially in atypical presentations. We also reviewed all causes of PSMA-avid lesions in the skin and subcutaneous tissues.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.