多囊卵巢综合征病例的表型和临床实验室数据:日本全国性调查。

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Journal of Obstetrics and Gynaecology Research Pub Date : 2024-10-30 DOI:10.1111/jog.16136
Hiroki Noguchi, Takeshi Iwasa, Akira Iwase, Haruhiko Kanasaki, Fuminori Kimura, Koji Kugu, Kazuki Saito, Tsuyoshi Baba, Tetsuaki Hara, Toshiya Matsuzaki
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引用次数: 0

摘要

目的:考虑到种族差异和肥胖状况,描述日本多囊卵巢综合征(PCOS)目前的表型和临床实验室数据:方法:通过一项日本全国性调查,收集了 986 例多囊卵巢综合征病例和 965 例对照病例的数据。对肥胖/超重(体重指数 [BMI] ≥25 kg/m2)和非肥胖/超重(体重指数 2)病例进行了比较:结果:日本的多囊卵巢综合症病例主要涉及非肥胖/超重患者,占所有病例的 75%。在非肥胖/超重的多囊卵巢综合征病例中,闭经和临床/生化雄激素过高的发生率明显低于肥胖/超重的多囊卵巢综合征病例,而血清黄体生成素(LH)水平升高的比例则明显高于肥胖/超重的多囊卵巢综合征病例。尽管多毛症在日本的发病率仅为 13.5%,但在日本妇产科学会(JSOG)的多毛症诊断标准中,除了血清总睾酮水平升高外,多毛症的检出率增加了 30.4%。根据采血时间进行评估时,在主诉月经周期不规律的初诊时(在确认没有直径≥1厘米的卵泡后)测定的LH水平和LH/卵泡刺激素比值明显高于月经周期的第2-3天或第4-6天:结论:包括肥胖状态在内的种族差异影响了日本多囊卵巢综合征患者的表型和临床实验室数据,如临床/生化高雄激素的发生率和基础 LH 水平的升高率。将多毛症纳入 JSOG 2024 标准将提高多囊卵巢综合征诊断的准确性,并加强与鹿特丹 2003 标准的一致性。测量基础 LH 水平有助于评估日本多囊卵巢综合症病例以及亚洲瘦弱多囊卵巢综合症病例的内分泌特征,但采血时间会影响结果。
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Phenotypes and clinical laboratory data for polycystic ovary syndrome cases: A nationwide survey in Japan.

Aim: Describe the current phenotypes and clinical laboratory data regarding polycystic ovary syndrome (PCOS) in Japan, taking into account ethnic differences and obesity status.

Methods: Data for 986 PCOS cases and 965 control cases were collected using a nationwide survey in Japan. Obese/overweight (body mass index [BMI] ≥25 kg/m2) and non-obese/overweight (BMI <25 kg/m2) cases were compared.

Results: Japanese PCOS cases predominantly involved non-obese/overweight patients, accounting for 75% of all cases. Among non-obese/overweight PCOS cases, the incidence of both amenorrhea and clinical/biochemical hyperandrogenism was significantly lower than in obese/overweight PCOS cases, whereas the rate of elevated serum luteinizing hormone (LH) level was significantly higher. Even though the incidence of hirsutism in Japan is only 13.5%, the detection rate for hyperandrogenism increased by as much as 30.4% when hirsutism was added to the Japan Society of Obstetrics and Gynecology (JSOG) criteria for the diagnosis of hyperandrogenism in addition to elevated serum total testosterone level. When evaluated based on timing of blood sampling, the LH level and LH/follicle-stimulating hormone ratio determined at the initial consultation involving a chief complaint of irregular menstrual cycle (after confirming the absence of follicles measuring ≥1 cm in diameter) were significantly higher than on days 2-3 or 4-6 of the menstrual cycle.

Conclusions: Ethnic differences, including obesity status, affected the phenotype and clinical laboratory data of Japanese PCOS patients, such as the incidence rates of clinical/biochemical hyperandrogenism and the rate of elevated basal LH level. Adding hirsutism to the JSOG 2024 criteria would enhance the accuracy of PCOS diagnosis and enhance consistency with the Rotterdam 2003 criteria. Measuring basal LH level is useful for assessing the endocrinologic characteristics of Japanese PCOS cases, as well as lean Asian PCOS cases, but the timing of blood sampling can affect the result.

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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
376
审稿时长
3-6 weeks
期刊介绍: The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.
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