炎症性肠病的肠道微生物和人类基因特征会增加合并精神障碍的风险。

IF 4.7 2区 医学 Q1 GENETICS & HEREDITY NPJ Genomic Medicine Pub Date : 2024-10-29 DOI:10.1038/s41525-024-00440-w
Junho Lee, Shin Ju Oh, Eunji Ha, Ga Young Shin, Hyo Jong Kim, Kwangwoo Kim, Chang Kyun Lee
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引用次数: 0

摘要

炎症性肠病(IBD)患者合并精神障碍(CMD)的发病率很高,这一点已得到充分证实。本研究通过综合分析 507 名 IBD 患者和 75 名对照组的人类变异、肠道微生物组和焦虑/抑郁估计值,深入探讨了 CMD 与 IBD 之间错综复杂的关系。值得注意的是,与对照组相比,IBD 患者,尤其是 CMD 患者的多样性较低。与对照组相比,我们在 IBD 患者中发现了 106 个不同的丰富类群(DAT),其中 21 个类群可将受 CMD 影响的 IBD 患者与未受 CMD 影响的 IBD 患者区分开来。微生物 IBD 风险评分反映了个体的 IBD 微生物负担,与未患 CMD 的患者相比,受 CMD 影响的患者中的 IBD 风险特征显著丰富。此外,有一种 IBD 风险变体可能会调节 IBD/CMD 相关 DAT 的丰度,这表明 IBD 风险变体与 CMD 中的菌群失调之间存在相互作用。我们的研究强调了 IBD 相关肠道菌群失调在 IBD 患者易患 CMD 中的关键作用,其中部分作用是通过基因变异介导的机制实现的。
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Gut microbial and human genetic signatures of inflammatory bowel disease increase risk of comorbid mental disorders.

The high prevalence of comorbid mental disorders (CMDs) in patients with inflammatory bowel disease (IBD) is well-documented. This study delves into the intricate CMD-IBD relationship through comprehensive analyses using human variants, gut microbiome, and anxiety/depression estimates from a cohort of 507 IBD patients and 75 controls. Notably, patients with IBD, especially those with CMD, exhibited lower diversity than controls. We identified 106 differentially abundant taxa (DATs) in IBD patients compared to controls and 21 DATs distinguishing CMD-affected from CMD-free IBD patients. Microbial IBD-risk scores, reflecting an individual's microbial burden for IBD, revealed a significant enrichment of IBD-risk signatures in CMD-affected patients compared to CMD-free patients. Additionally, there was an IBD-risk variant potentially regulating the abundance of an IBD/CMD-associated DAT, suggesting an interplay between IBD-risk variants and dysbiosis in CMD. Our investigation underscores the pivotal role of IBD-associated gut dysbiosis in predisposing IBD patients to CMD, partially through genetic variant-mediated mechanisms.

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来源期刊
NPJ Genomic Medicine
NPJ Genomic Medicine Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
1.90%
发文量
67
审稿时长
17 weeks
期刊介绍: npj Genomic Medicine is an international, peer-reviewed journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine. The journal defines genomic medicine as "diagnosis, prognosis, prevention and/or treatment of disease and disorders of the mind and body, using approaches informed or enabled by knowledge of the genome and the molecules it encodes." Relevant and high-impact papers that encompass studies of individuals, families, or populations are considered for publication. An emphasis will include coupling detailed phenotype and genome sequencing information, both enabled by new technologies and informatics, to delineate the underlying aetiology of disease. Clinical recommendations and/or guidelines of how that data should be used in the clinical management of those patients in the study, and others, are also encouraged.
期刊最新文献
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