口腔鳞状细胞癌初次手术和同侧颈部切除术后颈部放疗量对长期未刺激唾液流量的影响

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-10-30 DOI:10.1002/hed.27988

Claire M Rooney, Shao Hui Huang, Jie Su, Scott Bratman, John Cho, John de Almeida, Michael Glogauer, David Goldstein, Ezra Hahn, Ali Hosni, Andrew Hope, Jonathan Irish, John Kim, Brian O'Sullivan, Jolie Ringash, Anna Spreafico, Jillian Tsai, John Waldron, Christopher Yao, Erin Watson, Andrew McPartlin

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引用次数: 0

摘要

背景：我们研究了口腔SCC（OSCC）术后放疗量（PORT）与唾液功能的关系：我们研究了口腔SCC（OSCC）术后放疗（PORT）量与唾液功能的关系：2005-2021年接受PORT治疗的OSCC患者在PORT前、PORT后6个月和/或12个月接受了改良席尔默试验（MST）。根据 PORT 容量比较唾液分泌过少率。MVA确定了慢性唾液分泌过少的预测因素：在 165 名符合条件的患者中，88 人（53%）接受了双侧 PORT，66 人（40%）接受了同侧 PORT，11 人（7%）接受了无颈部 PORT（仅初级）。基线特征相似，但更多的 N2b/N2c 疾病患者接受了双侧 PORT 而不是同侧或无颈（60% vs. 36% vs. 0%, p 结论：PORT 容量的增加可预测唾液功能：PORT 容量的增加可预测唾液功能的恢复和慢性唾液分泌过少的情况，为治疗方案的讨论提供参考。

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Impact of Postoperative Neck Radiotherapy Volumes on Long-Term Unstimulated Saliva Flow Following Primary Surgery and Ipsilateral Neck Dissection for Oral Cavity Squamous Cell Carcinoma.

Background: We investigate the association of postoperative radiotherapy (PORT) volumes and salivary function in oral cavity SCC (OSCC).

Methods: OSCC patients undergoing PORT 2005-2021 underwent modified Schirmer test (MST) pre-PORT, 6 and/or 12 months post-PORT. Hyposalivation rates were compared by PORT volumes. MVA identified predictors for chronic hyposalivation.

Results: Among 165 eligible patients, 88 (53%) received bilateral, 66 (40%) ipsilateral, and 11 (7%) no-neck (primary-only) PORT. Baseline characteristics were similar, except more N2b/N2c disease received bilateral PORT vs. ipsilateral or no-neck (60% vs. 36% vs. 0%, p < 0.001). Baseline hyposalivation was similar (26% vs. 30% vs. 18%, p = 0.67). Hyposalivation occurred more frequently in bilateral vs. ipsilateral vs. no-neck PORT at 6 (90% vs. 62% vs. 9%) and 12 months (90% vs. 48% vs. 0%) (both p < 0.001). On MVA, bilateral neck PORT and smoking predicted chronic hyposalivation.

Conclusion: Increasing PORT volumes predict saliva function recovery and chronic hyposalivation, informing treatment discussions.

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.