Regioselective functionalization of cellulose nanomaterial for advanced application

Cellulose nanomaterials (CNMs) with their remarkable properties and abundant natural sources have emerged as a versatile platform for material science. However, their widespread adoption to develop novel applications often hinges on precise control over their surface chemistry. Regioselective functionalization, i.e., the ability to modify specific hydroxy groups on the cellulose backbone or aldehyde reducing end group (REG), offers unparalleled control on their surface chemistry. This review highlights the exciting developments in regioselective functionalization of CNMs and their impacts on structure-property relationships. Key factors that influence regioselectivity are examined and exciting applications of regioselectively functionalized CNMs are reviewed. This review also highlights the need for efficient, large-scale regioselective functionalization techniques and identifies key areas for future research.