生物活性介孔二氧化硅材料辅助癌症免疫疗法

IF 12.8 1区 医学 Q1 ENGINEERING, BIOMEDICAL Biomaterials Pub Date : 2024-10-25 DOI:10.1016/j.biomaterials.2024.122919
Jiali Liu , Jiying Liu , Yaxin Wang , Fangman Chen , Yan He , Xiaochun Xie , Yiling Zhong , Chao Yang
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引用次数: 0

摘要

免疫疗法最初被认为是训练肿瘤微环境(TME)和淋巴组织中的免疫细胞以引起强烈抗肿瘤反应的一种强有力的方法。然而,临床癌症免疫疗法仍面临着免疫原性有限和免疫反应不足等挑战。利用介孔二氧化硅(MS)材料在可控药物和免疫调节剂释放方面的优势,最近的研究重点是设计具有内在免疫调节功能的介孔二氧化硅,以促进稳健、系统和安全的抗肿瘤反应。本综述将讨论生物活性 MS 材料在应对免疫疗法挑战方面取得的进展。除了在按需递送和释放药物以应对肿瘤组织和器官方面的作用外,我们还强调了生物活性 MS 在通过诱导肿瘤细胞免疫原性细胞死亡、调节免疫细胞活性和促进肿瘤免疫细胞相互作用来协调局部免疫反应方面的内在功能。此外,我们还强调了生物活性 MS 在招募和激活淋巴组织内的免疫细胞以启动抗肿瘤疫苗接种方面的优势。综述还涵盖了 MS 辅助免疫疗法面临的挑战、潜在的解决方案以及未来展望。随着对材料-生物相互作用的深入了解,合理设计具有复杂生物活性和可控响应性的 MS 将为提高个性化免疫疗法的效果带来巨大希望。
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Bioactive mesoporous silica materials-assisted cancer immunotherapy
Immunotherapy is initially envisioned as a powerful approach to train immune cells within the tumor microenvironment (TME) and lymphoid tissues to elicit strong anti-tumor responses. However, clinical cancer immunotherapy still faces challenges, such as limited immunogenicity and insufficient immune response. Leveraging the advantages of mesoporous silica (MS) materials in controllable drug and immunomodulator release, recent efforts have focused on engineering MS with intrinsic immunoregulatory functions to promote robust, systemic, and safe anti-tumor responses. This review discusses advances in bioactive MS materials that address the challenges of immunotherapy. Beyond their role in on-demand delivery and drug release in response to the TME, we highlight the intrinsic functions of bioactive MS in orchestrating localized immune responses by inducing immunogenic cell death in tumor cells, modulating immune cell activity, and facilitating tumor-immune cell interactions. Additionally, we emphasize the advantages of bioactive MS in recruiting and activating immune cells within lymphoid tissues to initiate anti-tumor vaccination. The review also covers the challenges of MS-assisted immunotherapy, potential solutions, and future outlooks. With a deeper understanding of material-bio interactions, the rational design of MS with sophisticated bioactivities and controllable responsiveness holds great promise for enhancing the outcomes of personalized immunotherapy.
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来源期刊
Biomaterials
Biomaterials 工程技术-材料科学:生物材料
CiteScore
26.00
自引率
2.90%
发文量
565
审稿时长
46 days
期刊介绍: Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.
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